Guan Zhengrong, Osmond David A, Inscho Edward W
Department of Physiology, Medical College of Georgia, CA Building, CA3137, 1120 15th Street, Augusta, GA 30912, USA.
Exp Biol Med (Maywood). 2007 Jun;232(6):715-26.
The multiple roles of extracellular ATP and its metabolite adenosine include broad areas, such as regulating vascular tone and inducing inflammation. This review will discuss purinoceptor-induced effects on renal vascular resistance, highlighting the key experiments providing a significant contribution to our current understanding of autoregulatory mechanisms. Emphasis will be placed on the purinoceptor subtypes involved in autoregulatory control by ATP and adenosine. Additionally, the role of purinoceptors in hypertension-associated impairment of autoregulatory efficiency will be discussed.
细胞外ATP及其代谢产物腺苷的多种作用涵盖广泛领域，如调节血管张力和引发炎症。本综述将讨论嘌呤受体对肾血管阻力的影响，重点介绍那些为我们当前对自身调节机制的理解做出重大贡献的关键实验。将着重探讨参与ATP和腺苷自身调节控制的嘌呤受体亚型。此外，还将讨论嘌呤受体在高血压相关的自身调节效率受损中的作用。
