Sacco Sandra M, Power Krista A, Chen Jianmin, Ward Wendy E, Thompson Lilian U
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College Street, Toronto, ON, Canada.
Exp Biol Med (Maywood). 2007 Jun;232(6):754-61.
Some premenopausal breast cancer patients use phytoestrogen-rich soy and flaxseed to alleviate side effects induced by drugs such as tamoxifen (TAM). Lignan-rich flaxseed protects against breast cancer and increases the effectiveness of TAM. This study determined the interactive effects of lignan-rich sesame seed (SS) and TAM on estrogen-responsive MCF-7 breast tumor growth and bone health in ovariectomized athymic mice under premenopausal-simulated conditions. Ovariectomized mice with an estrogen implant and established MCF-7 tumors were treated for 8 weeks as follows: (i) positive control fed basal diet (BD), (ii) SS group fed BD supplemented with 10% ground SS, (iii) TAM group with TAM implant fed BD, (iv) SS + TAM group with TAM implant fed BD supplemented with 10% SS, and (v) negative control fed BD with no estrogen implant. Palpable tumor data, adjusted for body weight, showed that SS does not inhibit MCF-7 tumor growth and tends to negate the tumor inhibitory effect of TAM by increasing cell proliferation and reducing apoptosis. SS alone and combined with TAM enhanced femur biomechanical strength but caused no differences in bone mineral content or bone mineral density in either the femur or lumbar vertebrae. SS is not protective and interacts adversely with TAM in MCF-7 breast tumors but induces beneficial effects on bone both alone and when combined with TAM.
一些绝经前乳腺癌患者使用富含植物雌激素的大豆和亚麻籽来缓解他莫昔芬（TAM）等药物引起的副作用。富含木脂素的亚麻籽可预防乳腺癌并提高TAM的疗效。本研究确定了在模拟绝经前条件下，富含木脂素的芝麻籽（SS）与TAM对去卵巢无胸腺小鼠雌激素反应性MCF-7乳腺肿瘤生长和骨骼健康的交互作用。对植入雌激素且已形成MCF-7肿瘤的去卵巢小鼠进行8周治疗，具体如下：（i）阳性对照组喂食基础饮食（BD）；（ii）SS组喂食添加10%磨碎芝麻籽的BD；（iii）TAM组植入TAM并喂食BD；（iv）SS + TAM组植入TAM并喂食添加10% SS的BD；（v）阴性对照组喂食无雌激素植入的BD。经体重校正的可触及肿瘤数据显示，SS不抑制MCF-7肿瘤生长，且倾向于通过增加细胞增殖和减少凋亡来抵消TAM的肿瘤抑制作用。单独使用SS以及与TAM联合使用均可提高股骨生物力学强度，但对股骨或腰椎的骨矿物质含量或骨矿物质密度均无影响。在MCF-7乳腺肿瘤中，SS无保护作用且与TAM产生不良相互作用，但单独使用以及与TAM联合使用时均对骨骼产生有益影响。
