大豆油和芝麻油通过类雌激素机制对去卵巢大鼠的护骨作用。
Osteoprotective effect of soybean and sesame oils in ovariectomized rats via estrogen-like mechanism.
机构信息
Physiology Division, Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
出版信息
Cytotechnology. 2014 Mar;66(2):335-43. doi: 10.1007/s10616-013-9580-4. Epub 2013 Jun 8.
Abstract
The purpose of the present study was to investigate the osteoprotective effects of soybean oil (SbO) and sesame oil (SO) in ovarictomized (OVX) rats. The results indicated that the OVX rats exhibited a significant decrease in Ca and P level in both serum and bone, the activities of the antioxidant enzymes SOD and CAT and the antioxidant biomarker GSH accompanied with a marked increase in the oxidative stress markers MDA and PC, the inflammatory indices (TNF-α, CRP levels, WBCs counts and ACP activity) in, both, bone and serum. Supplementating the diet of the OVX rats with SbO (15 % w/w) or SO (10 % w/w) for 2 months to resulted in modulation of the alterations in all tested parameters and succeeded to restore minerals, antioxidant enzymes, antioxidant biomarkers, oxidative stress markers, inflammatory indices, and WBCs counts. It could be concluded that the consumption of diets supplemented with SbO or SO might be useful for preventing bone loss caused by estrogen deficiency in ovariectomy status.
摘要
本研究旨在探讨大豆油（SbO）和芝麻油（SO）对去卵巢（OVX）大鼠的护骨作用。结果表明，OVX 大鼠的血清和骨中钙和磷水平显著下降，抗氧化酶 SOD 和 CAT 的活性以及抗氧化生物标志物 GSH 下降，同时氧化应激标志物 MDA 和 PC、骨和血清中的炎症指标（TNF-α、CRP 水平、白细胞计数和 ACP 活性）显著增加。在 OVX 大鼠的饮食中补充 SbO（15%w/w）或 SO（10%w/w）2 个月，可调节所有测试参数的变化，并成功恢复矿物质、抗氧化酶、抗氧化生物标志物、氧化应激标志物、炎症指标和白细胞计数。可以得出结论，食用补充 SbO 或 SO 的饮食可能有助于预防去卵巢状态下雌激素缺乏引起的骨质流失。
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