Evren Cenk, Eken Mehmet, Ateş Günay, Bozkurt Ziya, Sanli Arif
Department of Otolaryngology, Dr. Lütfi Kirdar Kartal Training and Research Hospital, Istanbul, Turkey.
Kulak Burun Bogaz Ihtis Derg. 2007;17(2):100-4.
The aim of this study was to investigate the effect of topical mitomycin-C application before or after incisional myringotomy on patency times and to asess its use as an alternative to ventilation tube insertion.
Nineteen guinea pigs were divided into two groups. In the study group (n=11), mitomycin-C was applied in a concentration of 0.4 mg/ml over the perforation for five minutes before (n=6) or after (n=5) incisional myringotomies in both ears. Control animals (n=8) received 0.1 ml 0.09% NaCl for the same duration. Evaluations were made on days 1, 3, 5, 7, 10, 14, and 21. The patency times, otorrhea, and other complications were recorded.
Compared to controls (7.0+/-1.5 days), the mean patency times of perforations were significantly longer in mitomycin-C treated groups before (11.6+/-5.2 days) and after (14.2+/-4.7 days) incisional myringotomies (p<0.05). Patency times did not differ significantly between the two mitomycin-C groups. None of the ears exhibited permanent perforation.
The length of patency provided by mitomycin-C is not sufficient for optimal ventilation in otitis media with effusion. However, in cases requiring shorter patency times, mitomycin-C application before or after myringotomy may be an alternative to ventilation tube insertion.
本研究旨在探讨在鼓膜切开术前或术后局部应用丝裂霉素-C对穿孔通畅时间的影响，并评估其作为鼓膜置管替代方法的应用效果。
19只豚鼠分为两组。研究组（n = 11），在双耳鼓膜切开术前（n = 6）或术后（n = 5），以0.4 mg/ml的浓度在穿孔处应用丝裂霉素-C 5分钟。对照组动物（n = 8）在相同时间内接受0.1 ml 0.09%氯化钠溶液。在第1、3、5、7、10、14和21天进行评估。记录穿孔通畅时间、耳漏及其他并发症。
与对照组（7.0±1.5天）相比，丝裂霉素-C治疗组在鼓膜切开术前（11.6±5.2天）和术后（14.2±4.7天）穿孔的平均通畅时间显著延长（p<0.05）。两个丝裂霉素-C组之间的通畅时间无显著差异。所有耳朵均未出现永久性穿孔。
丝裂霉素-C提供的通畅时间长度不足以满足分泌性中耳炎的最佳通气需求。然而，在需要较短通畅时间的情况下，鼓膜切开术前或术后应用丝裂霉素-C可能是鼓膜置管的一种替代方法。
