• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Human granulocyte-macrophage colony-stimulating factor is a growth factor active on human ovarian cancer cells.人粒细胞巨噬细胞集落刺激因子是一种对人卵巢癌细胞有活性的生长因子。
Jpn J Cancer Res. 1991 Nov;82(11):1196-8. doi: 10.1111/j.1349-7006.1991.tb01779.x.
2
Human granulocyte colony-stimulating factor: biologic activities and receptor characterization on hematopoietic cells and small cell lung cancer cell lines.人粒细胞集落刺激因子：造血细胞和小细胞肺癌细胞系的生物学活性及受体特性
Blood. 1990 Feb 15;75(4):851-7.
3
Stimulation of granulopoiesis by transforming growth factor beta: synergy with granulocyte/macrophage-colony-stimulating factor.转化生长因子β对粒细胞生成的刺激作用：与粒细胞/巨噬细胞集落刺激因子的协同作用
Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7190-4. doi: 10.1073/pnas.88.16.7190.
4
Modulation of the activity of a human granulocyte-macrophage colony-stimulating factor/interleukin-3 fusion protein (pIXY 321) by the macrocyclic lactone protein kinase C activator bryostatin 1.大环内酯类蛋白激酶C激活剂苔藓抑素1对人粒细胞-巨噬细胞集落刺激因子/白细胞介素-3融合蛋白（pIXY 321）活性的调节作用
Exp Hematol. 1993 Jul;21(7):893-900.
5
Effect of interleukin-4 on the growth of granulocyte-macrophage progenitor cells stimulated by hematopoietic growth factors.白细胞介素-4对造血生长因子刺激的粒细胞-巨噬细胞祖细胞生长的影响。
J UOEH. 1990 Jun 1;12(2):163-74. doi: 10.7888/juoeh.12.163.
6
Interactions among granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and IFN-gamma lead to enhanced proliferation of murine macrophage progenitor cells.粒细胞巨噬细胞集落刺激因子、巨噬细胞集落刺激因子和干扰素-γ之间的相互作用导致小鼠巨噬细胞祖细胞的增殖增强。
J Immunol. 1991 Sep 1;147(5):1542-7.
7
The in vitro effect of high-dose recombinant human erythropoietin on granulocyte-macrophage colony production in premature infants using a defined serum deprived cell culture system.使用特定血清剥夺细胞培养系统研究高剂量重组人促红细胞生成素对早产儿粒细胞-巨噬细胞集落生成的体外作用。
Br J Haematol. 1992 Jul;81(3):325-30. doi: 10.1111/j.1365-2141.1992.tb08235.x.
8
Lack of effect of granulocyte-macrophage and granulocyte colony-stimulating factors on cultured human endothelial cells.粒细胞巨噬细胞集落刺激因子和粒细胞集落刺激因子对培养的人内皮细胞无作用。
Blood. 1991 Apr 15;77(8):1675-80.
9
Kinetic response of human marrow myeloid progenitor cells to in vivo treatment of patients with granulocyte colony-stimulating factor is different from the response to treatment with granulocyte-macrophage colony-stimulating factor.人类骨髓髓系祖细胞对粒细胞集落刺激因子体内治疗患者的动力学反应不同于对粒细胞-巨噬细胞集落刺激因子治疗的反应。
Exp Hematol. 1994 Jan;22(1):100-2.
10
Growth characteristics of marrow hematopoietic progenitor/precursor cells from patients on a phase I clinical trial with purified recombinant human granulocyte-macrophage colony-stimulating factor.接受纯化重组人粒细胞巨噬细胞集落刺激因子I期临床试验患者的骨髓造血祖细胞/前体细胞的生长特性
Exp Hematol. 1988 Aug;16(7):594-602.

引用本文的文献

1
Cytokine biomarkers and chronic pain: association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation tenderness.细胞因子生物标志物与慢性疼痛：基因、转录和循环蛋白与颞下颌关节紊乱病和广泛触压痛的关联。
Pain. 2011 Dec;152(12):2802-2812. doi: 10.1016/j.pain.2011.09.005. Epub 2011 Oct 14.
2
Hematopoietic growth factors and treatment of testicular cancer: biological interactions, routine use and dose-intensive chemotherapy.造血生长因子与睾丸癌治疗：生物学相互作用、常规应用及剂量密集化疗
Ann Hematol. 1996 Jan;72(1):1-9. doi: 10.1007/BF00663009.

本文引用的文献

1
Doxorubicin cytotoxicity to P388 lymphocytic leukemia as determined by alkaline elution and established assays.通过碱性洗脱和既定检测方法测定阿霉素对P388淋巴细胞白血病的细胞毒性。
Anticancer Res. 1986 Nov-Dec;6(6):1297-304.
2
High-affinity binding of granulocyte-macrophage colony-stimulating factor to normal and leukemic human myeloid cells.粒细胞巨噬细胞集落刺激因子与正常及白血病人类髓系细胞的高亲和力结合。
Proc Natl Acad Sci U S A. 1986 Feb;83(3):669-73. doi: 10.1073/pnas.83.3.669.
3
A putative new growth factor in ascitic fluid from ovarian cancer patients: identification, characterization, and mechanism of action.
Cancer Res. 1988 Mar 1;48(5):1066-71.
4
Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin.人粒细胞巨噬细胞集落刺激因子是一种对多种非造血起源细胞类型具有活性的生长因子。
Proc Natl Acad Sci U S A. 1988 Dec;85(23):9253-7. doi: 10.1073/pnas.85.23.9253.
5
The granulocyte-macrophage colony-stimulating factors.粒细胞-巨噬细胞集落刺激因子
Science. 1985 Jul 5;229(4708):16-22. doi: 10.1126/science.2990035.
6
Characterization of the human granulocyte-macrophage colony-stimulating factor receptor.人粒细胞-巨噬细胞集落刺激因子受体的特性分析
J Biol Chem. 1988 Feb 5;263(4):1834-41.
7
Constitutive production of macrophage colony-stimulating factor by human ovarian and breast cancer cell lines.人卵巢癌细胞系和乳腺癌细胞系组成性产生巨噬细胞集落刺激因子。
J Clin Invest. 1989 Mar;83(3):921-6. doi: 10.1172/JCI113977.
8
Nonhematopoietic tumor cells express functional GM-CSF receptors.非造血肿瘤细胞表达功能性粒细胞-巨噬细胞集落刺激因子受体。
Blood. 1989 Mar;73(4):1033-7.
9
Hemopoietins in oncology: factoring out myelosuppression.肿瘤学中的造血生长因子：排除骨髓抑制因素
J Clin Oncol. 1989 Feb;7(2):151-5. doi: 10.1200/JCO.1989.7.2.151.
10
Various human hematopoietic growth factors (interleukin-3, GM-CSF, G-CSF) stimulate clonal growth of nonhematopoietic tumor cells.
Blood. 1989 Jan;73(1):80-3.

人粒细胞巨噬细胞集落刺激因子是一种对人卵巢癌细胞有活性的生长因子。

Human granulocyte-macrophage colony-stimulating factor is a growth factor active on human ovarian cancer cells.

作者信息

Cimoli G, Russo P, Billi G, Mariani G L, Rovini E, Venturini M

机构信息

Department of Chemical Carcinogenesis, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.

出版信息

Jpn J Cancer Res. 1991 Nov;82(11):1196-8. doi: 10.1111/j.1349-7006.1991.tb01779.x.

DOI:10.1111/j.1349-7006.1991.tb01779.x
PMID:1752777
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5918337/
Abstract

Human granulocyte-macrophage colony-stimulating factor (GM-CSF) is a regulatory glycoprotein that stimulates the production of granulocytes and macrophages from committed hematopoietic progenitor cells both in vitro and in vivo. In this report, we show that recombinant human GM-CSF enhances colony formation by nonhematopoietic human ovarian cancer cell lines, IGROV-1, A2774, ME-180, Pa-1 and A2780. GM-CSF also enhanced the colony formation by cells obtained from fresh ascites of a patient with ovarian mucinous cystadenocarcinoma and a patient with serous papillary ovarian carcinoma. Our observations were made with GM-CSF concentrations between 0.1 to 1 ng/ml; these concentrations are equivalent to the dosages generally used for bone marrow recovery after chemotherapy.

摘要

人粒细胞巨噬细胞集落刺激因子（GM-CSF）是一种调节性糖蛋白，可在体外和体内刺激定向造血祖细胞产生粒细胞和巨噬细胞。在本报告中，我们表明重组人GM-CSF可增强非造血性人卵巢癌细胞系IGROV-1、A2774、ME-180、Pa-1和A2780的集落形成。GM-CSF还增强了从一名卵巢黏液性囊腺癌患者和一名浆液性乳头状卵巢癌患者的新鲜腹水中获得的细胞的集落形成。我们的观察是在GM-CSF浓度为0.1至1 ng/ml之间进行的；这些浓度相当于化疗后骨髓恢复通常使用的剂量。