Dedhar S, Gaboury L, Galloway P, Eaves C
Department of Advanced Therapeutics, British Columbia Cancer Research Centre, Vancouver, Canada.
Proc Natl Acad Sci U S A. 1988 Dec;85(23):9253-7. doi: 10.1073/pnas.85.23.9253.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a member of a family of glycoprotein hormones that stimulate the proliferation and differentiation of hemopoietic cells in vitro and in vivo. We now report that human GM-CSF can also stimulate the proliferation of two osteogenic sarcoma cell lines, a breast carcinoma cell line, a simian virus 40-transformed marrow stromal cell line, and normal marrow fibroblast precursors. These findings suggest a more general regulatory function of GM-CSF on nonhemopoietic cell types than previously anticipated. They also raise the possibility of adverse side effects of GM-CSF therapy in patients whose malignant cells may be directly stimulated by this molecule and suggest a previously unanticipated role of GM-CSF gene activation in the evolution of solid tumors and in the pathogenesis of myelofibrosis.
粒细胞巨噬细胞集落刺激因子（GM-CSF）是一类糖蛋白激素家族的成员，可在体内外刺激造血细胞的增殖和分化。我们现在报告，人GM-CSF还可刺激两种骨肉瘤细胞系、一种乳腺癌细胞系、一种猿猴病毒40转化的骨髓基质细胞系以及正常骨髓成纤维细胞前体的增殖。这些发现表明，GM-CSF对非造血细胞类型的调节功能比以前预期的更为普遍。它们还增加了GM-CSF治疗对恶性细胞可能直接受该分子刺激的患者产生不良副作用的可能性，并提示GM-CSF基因激活在实体瘤演变和骨髓纤维化发病机制中具有以前未预料到的作用。
