Hernandez L, Parada M, Baptista T, Schwartz D, West H L, Mark G P, Hoebel B G
Department of Psychology, Princeton University, Princeton, N.J. 08544-1010.
J Clin Psychiatry. 1991 Dec;52 Suppl:32-40.
Microdialysis was used to measure changes in extracellular serotonin in the hypothalamus of rats while they engaged in feeding behavior or received drug treatments used to treat feeding disorders and affective disorders in humans. Hypothalamic serotonin increased significantly relative to controls in response to (1) intraperitoneal tryptophan after food deprivation, (2) the smell of food and eating a meal, (3) a conditioned taste aversion, (4) d-fenfluramine and fluoxetine, and (5) an amphetamine challenge test after chronic low doses of lithium. In some cases, increases correlated with nonspecific behavioral arousal were seen in the hippocampus. The results suggest that diet, drug, and behavioral therapies, alone or combined, can be used to preferentially modify hypothalamic serotonin in the control of behavioral, emotional, and endocrine problems.
微透析技术被用于测量大鼠下丘脑细胞外5-羟色胺的变化，这些大鼠要么正在进食，要么接受用于治疗人类进食障碍和情感障碍的药物治疗。与对照组相比，下丘脑5-羟色胺在以下情况下显著增加：(1) 禁食后腹腔注射色氨酸；(2) 食物的气味和进食；(3) 条件性味觉厌恶；(4) d-芬氟拉明和氟西汀；(5) 慢性低剂量锂盐后进行的苯丙胺激发试验。在某些情况下，海马体中也观察到与非特异性行为唤醒相关的增加。结果表明，饮食、药物和行为疗法单独或联合使用，可用于在控制行为、情绪和内分泌问题时优先调节下丘脑5-羟色胺。
