Chandler-Laney Paula C, Castañeda Edward, Viana Jason B, Oswald Kimberly D, Maldonado Christine R, Boggiano Mary M
Department of Psychology, Behavioral Neuroscience Division, University of Alabama at Birmingham, Birmingham, Alabama 35294-1170, USA.
Int J Eat Disord. 2007 Mar;40(2):136-42. doi: 10.1002/eat.20349.
This study replicated a model of stress-induced binge-eating in rats with a history of caloric restriction (HCR), tested their response to SSRI (fluoxetine) treatment, and explored changes in brain monoamine levels.
Young female rats with no-HCR/no-Stress, no-HCR/Stress, HCR/no-Stress, and HCR+Stress (binge-eating) were treated with fluoxetine. Post-mortem levels of serotonin, dopamine, and metabolites were assessed from brain regions key to feeding and reward.
A 3 mg/kg dose of fluoxetine without effect in the no-HCR groups suppressed intake of HCR groups, normalizing the binge-eating of HCR/Stress rats. No differences in monoamines were detected in the hypothalamus or tegmentum but a strong positive relationship between accumbens serotonin and dopamine turnover in no-HCR rats was absent in rats with HCR.
Despite lack of hunger, a history of human-like dieting alters serotonin function in ways suggesting consequences not only to feeding but also control of reward and mood that are dependent on dopamine/serotonin interactions.
本研究复制了有热量限制史（HCR）大鼠的应激诱导暴饮暴食模型，测试了它们对选择性5-羟色胺再摄取抑制剂（SSRI，氟西汀）治疗的反应，并探究了脑单胺水平的变化。
对无热量限制/无应激、无热量限制/应激、有热量限制/无应激以及有热量限制+应激（暴饮暴食）的年轻雌性大鼠给予氟西汀治疗。从对进食和奖赏起关键作用的脑区评估5-羟色胺、多巴胺及其代谢产物的死后水平。
3mg/kg剂量的氟西汀对无热量限制组无作用，但抑制了有热量限制组的摄入量，使有热量限制/应激大鼠的暴饮暴食恢复正常。在下丘脑或被盖中未检测到单胺的差异，但在有热量限制的大鼠中，伏隔核5-羟色胺与多巴胺周转率之间不存在无热量限制大鼠中存在的强正相关关系。
尽管不存在饥饿，但类似人类节食的历史会改变5-羟色胺功能，这不仅对进食有影响，而且对依赖多巴胺/5-羟色胺相互作用的奖赏和情绪控制也有影响。
