Robinson J N, Forman R G, Lockwood G M, Hickey J B, Chapman M G, Barlow D H
Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington, Oxford, UK.
Hum Reprod. 1991 Oct;6(9):1291-3. doi: 10.1093/oxfordjournals.humrep.a137529.
Transient hyperprolactinaemia has been shown to accompany the procedure of oocyte retrieval under laparoscopic control. This study was concerned with establishing whether transvaginal oocyte retrieval was also associated with hyperprolactinaemia and whether the hyperprolactinaemic response was dependent on the method of anaesthesia/analgesia employed. Two distinct patterns were recorded. Oocyte retrieval under general anaesthesia was accompanied by a rapid rise in prolactin levels, which peaked after 40 min. Oocyte retrieval under intravenous sedation was associated with a slow rise in circulating prolactin concentrations. Significant differences in the prolactin rise between the general anaesthesia and sedation groups appeared within 10 min of the start of the procedure. It is concluded that although the surgical stress of oocyte recovery is associated with mild transient hyperprolactinaemia, most of the hyperprolactinaemic response is due to the anaesthetic.
已证实，在腹腔镜控制下进行卵母细胞取卵手术时会伴随短暂性高催乳素血症。本研究旨在确定经阴道取卵是否也与高催乳素血症有关，以及高催乳素血症反应是否取决于所采用的麻醉/镇痛方法。记录到两种不同的模式。全身麻醉下取卵伴随着催乳素水平的快速上升，在40分钟后达到峰值。静脉镇静下取卵与循环催乳素浓度的缓慢上升有关。全身麻醉组和镇静组之间催乳素升高的显著差异在手术开始后10分钟内出现。得出的结论是，虽然卵母细胞回收的手术应激与轻度短暂性高催乳素血症有关，但大多数高催乳素血症反应是由麻醉引起的。
