氧化型低密度脂蛋白在动脉粥样硬化形成中的作用。
Role of oxidized low density lipoprotein in atherogenesis.
作者信息
Witztum J L, Steinberg D
机构信息
Department of Medicine, University of California, San Diego, La Jolla 92093.
出版信息
J Clin Invest. 1991 Dec;88(6):1785-92. doi: 10.1172/JCI115499.
Abstract
Evidence to support an important role of oxidative modification in mediating the atherogenicity of LDL continues to grow. New hypotheses suggest mechanisms by which Ox-LDL or products of Ox-LDL can affect many components of the atherogenic process, including vasomotor properties and thrombosis, as well as lesion initiation and progression itself. These ideas suggest new approaches, that in combination with lowering of plasma cholesterol, could lead to the prevention of atherosclerosis and its complications.
摘要
支持氧化修饰在介导低密度脂蛋白致动脉粥样硬化性方面起重要作用的证据不断增加。新的假说提出了氧化型低密度脂蛋白或其产物能够影响动脉粥样硬化形成过程中许多成分的机制，包括血管舒缩特性和血栓形成，以及病变的起始和进展本身。这些观点提示了新的方法，与降低血浆胆固醇相结合，可能会预防动脉粥样硬化及其并发症。
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