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本文引用的文献

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Neuromonitoring of cochlea and auditory nerve with multiple extracted parameters during induced hypoxia and nerve manipulation.在诱导性缺氧和神经操作过程中，利用多个提取参数对耳蜗和听神经进行神经监测。
J Neural Eng. 2005 Jun;2(2):1-10. doi: 10.1088/1741-2560/2/2/001. Epub 2005 Mar 8.
2
Intraoperative monitoring of cochlear function using distortion product otoacoustic emissions (DPOAEs) in patients with cerebellopontine angle tumors.使用畸变产物耳声发射（DPOAE）对桥小脑角肿瘤患者进行术中耳蜗功能监测。
Otol Neurotol. 2004 Sep;25(5):818-25. doi: 10.1097/00129492-200409000-00028.
3
Combined intra-operative monitoring of hearing by means of auditory brainstem responses (ABR) and transtympanic electrocochleography (ECochG) during surgery of intra- and extrameatal acoustic neurinomas.在耳道内和耳道外听神经瘤手术期间，通过听性脑干反应（ABR）和经鼓膜电耳蜗图（ECochG）对听力进行联合术中监测。
Acta Neurochir (Wien). 2001 Oct;143(10):985-95; discussion 995-6. doi: 10.1007/s007010170003.
4
Acoustic evoked response following transection of the eighth nerve in the rat.大鼠第八神经横断后的听觉诱发反应。
Acta Neurochir (Wien). 2000;142(9):1037-45. doi: 10.1007/s007010070060.
5
Intraoperative monitoring during surgery for acoustic neuroma: benefits of an extratympanic intrameatal electrode.听神经瘤手术中的术中监测：鼓室外耳道内电极的益处
J Neurol Neurosurg Psychiatry. 1999 May;66(5):591-9. doi: 10.1136/jnnp.66.5.591.
6
Advances in monitoring of seventh and eighth cranial nerve function during posterior fossa surgery.后颅窝手术中第七和第八颅神经功能监测的进展
Am J Otol. 1998 Jul;19(4):503-12.
7
Monitoring auditory function during operations to remove acoustic tumors.在切除听神经瘤手术过程中监测听觉功能。
Am J Otol. 1996 May;17(3):452-60.
8
Tympanic and transtympanic electrocochleography in acoustic neuroma and vestibular nerve section surgery.听神经瘤和前庭神经切断术中的鼓膜和经鼓膜电耳蜗图检查
Am J Otol. 1993 Jan;14(1):63-9.
9
Intraoperative monitoring by transtympanic electrocochleography and brainstem electrical response audiometry in acoustic neuroma surgery.听神经瘤手术中经鼓膜电耳蜗图和脑干电反应测听的术中监测
Eur Arch Otorhinolaryngol. 1992;249(5):257-62. doi: 10.1007/BF00714488.

使用经鼓膜电耳蜗图在桥小脑角肿瘤手术中进行听力的术中监测。

Intraoperative monitoring of hearing during cerebellopontine angle tumor surgery using transtympanic electrocochleography.

作者信息

Morawski Krzysztof F, Niemczyk Kazimierz, Bohorquez Jorge, Marchel Andrzej, Delgado Rafael E, Ozdamar Ozcan, Telischi Fred F

机构信息

Department of Otolaryngology, Medical University of Warsaw, Warsaw, Poland.

出版信息

Otol Neurotol. 2007 Jun;28(4):541-5. doi: 10.1097/mao.0b013e3180577919.

DOI:10.1097/mao.0b013e3180577919
PMID:17529854
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2094124/
Abstract

OBJECTIVE

To investigate the use of transtympanic electrocochleography (TT-ECochG) analyzed on-line by a detector strategy software that made possible automatic extraction of TT-ECochG components intraoperatively in real-time domain.

PATIENTS

Fifteen patients with cerebellopontine angle tumor among 50 patients were included in this study.

INTERVENTION

All subjects were operated on via middle fossa or retrosigmoid approach. Pure-tone average (PTA) was measured at 0.5, 1.0, and 2.0 kHz, and calculations were performed before and after surgery. Auditory function was monitored intraoperatively via TT-ECochG, and analyzed data were displayed on-line.

MAIN OUTCOME MEASURES

TT-ECochG changes in morphology were described. Postoperative PTA elevation level correlated with TT-ECochG morphology changes occurring intraoperatively.

RESULTS

Analyzed on-line, TT-ECochG data were displayed as first negative peak of compound action potential amplitude and latency in time domain every 3 to 5 seconds. A good correlation between postoperative PTA elevation and TT-ECochG morphology changes was showed (Spearman rank test, R = +0.93; t(N-2) = 9.00; p < 0.0001).

CONCLUSION

TT-EcochG seemed to effectively mirror even minimal changes in auditory function during intraoperative monitoring in real-time domain. Developed strategy of on-line analysis makes the intraoperative hearing status assessment faster and easier.

摘要

目的

研究通过一种检测策略软件对经鼓膜电耳蜗图（TT - ECochG）进行在线分析，该软件能够在术中实时自动提取时域中的TT - ECochG成分。

患者

50例患者中有15例桥小脑角肿瘤患者纳入本研究。

干预措施

所有受试者均通过中颅窝或乙状窦后入路进行手术。在0.5、1.0和2.0 kHz频率下测量纯音平均听阈（PTA），并在手术前后进行计算。术中通过TT - ECochG监测听觉功能，并在线显示分析数据。

主要观察指标

描述TT - ECochG形态学变化。术后PTA升高水平与术中发生的TT - ECochG形态学变化相关。

结果

在线分析时，TT - ECochG数据每3至5秒在时域中显示为复合动作电位幅度和潜伏期的第一个负峰。术后PTA升高与TT - ECochG形态学变化之间显示出良好的相关性（Spearman秩检验，R = +0.93；t（N - 2）= 9.00；p < 0.0001）。

结论

TT - EcochG似乎能有效反映术中实时监测听觉功能的微小变化。开发的在线分析策略使术中听力状态评估更快、更容易。