Sami M H
Department of Medicine, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada.
J Clin Pharmacol. 1991 Nov;31(11):1081-4. doi: 10.1002/j.1552-4604.1991.tb03675.x.
Despite significant advances in recent years in the diagnosis and treatment of congestive heart failure, sudden unexpected cardiac death is still considered a major epidemiologic problem among those patients. This article lists some of the predisposing factors to the development of cardiac arrhythmias and sudden death in patients with congestive heart failure. These include electrolyte or autonomic nervous system inbalance, the use of certain anti-arrhythmic drugs, or intermittent myocardial ischemia. This paper shows that an advanced degree of left ventricular dysfunction and the preference frequent or complex ventricular arrhythmias appear to be major predictors of total and sudden mortality among patients with congestive heart failure. A screening of 24 hours ambulatory Holter monitor recording appears to be useful in identifying patients at risk of sudden cardiac death.
尽管近年来充血性心力衰竭的诊断和治疗取得了重大进展，但心脏性猝死在这些患者中仍然被认为是一个主要的流行病学问题。本文列出了一些导致充血性心力衰竭患者发生心律失常和猝死的诱发因素。这些因素包括电解质或自主神经系统失衡、某些抗心律失常药物的使用或间歇性心肌缺血。本文表明，左心室功能障碍的严重程度以及频发或复杂室性心律失常似乎是充血性心力衰竭患者全因死亡率和猝死的主要预测因素。24小时动态心电图监测筛查似乎有助于识别有心脏性猝死风险的患者。
