Bryan B A, D'Amore P A
Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA.
Cell Mol Life Sci. 2007 Aug;64(16):2053-65. doi: 10.1007/s00018-007-7008-z.
The members of the Rho family of small GTPases are involved in an array of cellular processes, including regulation of the actin cytoskeleton, cell polarity, microtubule dynamics, membrane transport, and transcription factor activity. Recent findings have implicated the Rho-proteins as key regulators of angiogenesis, modulating a diversity of cellular processes, including vascular permeability, extracellular matrix remodeling, migration, proliferation, morphogenesis, and survival.
小GTP酶Rho家族的成员参与了一系列细胞过程,包括肌动蛋白细胞骨架的调节、细胞极性、微管动力学、膜运输和转录因子活性。最近的研究结果表明,Rho蛋白是血管生成的关键调节因子,可调节多种细胞过程,包括血管通透性、细胞外基质重塑、迁移、增殖、形态发生和存活。