Randall Division of Cell and Molecular Biophysics, King's College London, , New Hunt's House, Guy's Campus, London SE1 1UL, UK.
Philos Trans R Soc Lond B Biol Sci. 2013 Sep 23;368(1629):20130013. doi: 10.1098/rstb.2013.0013. Print 2013.
Leucocytes migrate into and out of blood vessels at multiple points during their development and maturation, and during immune surveillance. In response to tissue damage and infection, they are rapidly recruited through the endothelium lining blood vessels into the tissues. Leukaemia cells also move in and out of the bloodstream during leukaemia progression. Rho GTPases are intracellular signalling proteins that regulate cytoskeletal dynamics and are key coordinators of cell migration. Here, we describe how different members of the Rho GTPase family act in leucocytes and leukaemia cells to regulate steps of transendothelial migration. We discuss how inhibitors of Rho signalling could be used to reduce leucocyte or leukaemia cell entry into tissues.
白细胞在其发育和成熟过程中以及在免疫监视期间，会在多个点进出血管。在组织损伤和感染的情况下，它们会迅速通过血管内皮细胞招募到组织中。白血病细胞在白血病进展过程中也会进出血流。Rho GTPases 是细胞内信号蛋白，可调节细胞骨架动态，是细胞迁移的关键协调因子。在这里，我们描述了 Rho GTPase 家族的不同成员如何在白细胞和白血病细胞中发挥作用，以调节跨内皮迁移的步骤。我们讨论了如何使用 Rho 信号抑制剂来减少白细胞或白血病细胞进入组织。
