Singhal Nimit, Selva-Nayagam Sudarshan, Brown Michael P
Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, SA, 5000, Australia.
J Neurooncol. 2007 Nov;85(2):229-30. doi: 10.1007/s11060-007-9403-6. Epub 2007 May 26.
Temozolomide is an alkylating agent used frequently in the management of gliomas. Although temozolomide is generally safe, rarely it can cause life threatening complications. Here we report the cases of two patients who developed prolonged and severe pancytopenia after low dose continuous temozolomide concurrently with cranial radiotherapy. The pancytopenia lasted two to six months. Both the patients were young, treatment naïve, and had temozolomide treatment for only approximately four weeks.
替莫唑胺是一种常用于治疗胶质瘤的烷化剂。尽管替莫唑胺总体上是安全的，但它很少会引起危及生命的并发症。在此，我们报告两例患者的病例，他们在低剂量连续使用替莫唑胺并同时进行颅脑放疗后，出现了长期且严重的全血细胞减少症。全血细胞减少症持续了两到六个月。这两名患者均为年轻人，此前未接受过治疗，且替莫唑胺治疗仅约四周时间。
