Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Mullana, Ambala, 133207, India.
School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India.
Naunyn Schmiedebergs Arch Pharmacol. 2024 Jan;397(1):41-57. doi: 10.1007/s00210-023-02660-w. Epub 2023 Aug 11.
Patients with glioblastoma multiforme and anaplastic astrocytoma are treated with temozolomide. Although it has been demonstrated that temozolomide increases GBM patient survival, it has also been connected to negative immune-related adverse effects. Numerous research investigations have shown that flavonoids have strong antioxidant and chemo-preventive effects. Consequently, it might lessen chemotherapeutic medicines' side effects while also increasing therapeutic effectiveness. The need for creating innovative, secure, and efficient drug carriers for cancer therapy has increased over time. Recent research indicates that exosomes have enormous potential to serve as carriers and cutting-edge drug delivery systems to the target cell. In recent years, researchers have been paying considerable attention to exosomes because of their favorable biodistribution, biocompatibility, and low immunogenicity. In the present review, the mechanistic information of the anti-glioblastoma effects of temozolomide and flavonoids coupled with their exosomal delivery to the targeted cell has been discussed. In addition, we discuss the safety aspects of temozolomide and flavonoids against glioma. The in-depth information of temozolomide and flavonoids action via exosomal delivery can unravel novel strategies to target Glioma.
替莫唑胺用于治疗多形性胶质母细胞瘤和间变性星形细胞瘤。尽管替莫唑胺已被证明可延长 GBM 患者的生存时间，但它也与负面的免疫相关不良反应有关。大量研究表明，类黄酮具有很强的抗氧化和化学预防作用。因此，它可能减轻化疗药物的副作用，同时提高治疗效果。随着时间的推移，对用于癌症治疗的创新、安全和有效的药物载体的需求不断增加。最近的研究表明，外泌体具有作为载体和先进的药物传递系统靶向靶细胞的巨大潜力。近年来，由于其有利的生物分布、生物相容性和低免疫原性，研究人员对外泌体给予了相当多的关注。在本综述中，讨论了替莫唑胺和类黄酮联合其递送至靶细胞的外泌体的抗神经胶质瘤作用的机制信息。此外，我们还讨论了替莫唑胺和类黄酮针对神经胶质瘤的安全性方面。通过外泌体递送来深入了解替莫唑胺和类黄酮的作用，可以为靶向神经胶质瘤的提供新策略。
