Vaidya Sucheta J, Hargrave Darren, Saran Frank, Britton Juliet, Soomal Rubin, Bouffet Eric
Paediatric Unit, The Royal Marsden Hospital NHS Foundation Trust, Downs Road, Sutton, Surrey, SM2 5PT, UK.
J Neurooncol. 2007 Jul;83(3):279-84. doi: 10.1007/s11060-006-9313-z. Epub 2007 May 26.
The purpose of this retrospective study was to investigate the pattern of recurrence in paediatric malignant gliomas.
We reviewed the notes, diagnostic imaging and treatment charts of 30 consecutive paediatric patients (age less than 18 years at diagnosis, range 0.5-17 years) presenting with a malignant glioma presenting to the paediatric oncology unit at the Royal Marsden Hospital over a 10-year period. The imaging at the time of first relapse was compared with the initial diagnostic scans to define a relapse as local, marginal or distant.
Median follow-up was 13 months (range 1-99 months). Twenty-four of 30 patients (80%) showed evidence of progression with a median time to progression of 8.5 months (range 3-64 months). Thirteen out of 24 patients developed local or marginal recurrences while 11/24 patients recurred at distant sites as site of first relapse (46%).
Our series suggests that the pattern of relapses in paediatric malignant gliomas could be different from that reported in adult studies as we observed a significant incidence of distant relapses. Larger prospective series need to be conducted to investigate the clinico-biological characteristics of the population at high risk for leptomeningeal dissemination.
本回顾性研究旨在调查儿童恶性胶质瘤的复发模式。
我们回顾了皇家马斯登医院儿科肿瘤科10年间收治的30例连续儿童患者（诊断时年龄小于18岁，范围0.5 - 17岁）的病历、诊断性影像学检查和治疗记录。将首次复发时的影像学检查与初始诊断扫描进行比较，以确定复发为局部、边缘性或远处性。
中位随访时间为13个月（范围1 - 99个月）。30例患者中有24例（80%）出现病情进展，中位进展时间为8.5个月（范围3 - 64个月）。24例患者中有13例出现局部或边缘性复发，而11/24例患者首次复发部位为远处（46%）。
我们的系列研究表明，儿童恶性胶质瘤的复发模式可能与成人研究报道的不同，因为我们观察到远处复发的发生率较高。需要开展更大规模的前瞻性系列研究，以调查软脑膜播散高危人群的临床生物学特征。
