van Dalen C J, Harding E, Parkin J, Blakey K, Cheng S, Pearce N E, Douwes J
Centre for Public Health Research, Research School of Public Health, Massey University, Wellington, New Zealand.
J Asthma. 2007 May;44(4):261-6. doi: 10.1080/02770900701246873.
Asthma control, defined by asthma symptoms and lung function, and asthma medication use, was assessed in 123 adolescent asthmatics. Sputum eosinophilia (>or= 2.5% eosinophils) and bronchial hyperresponsiveness (BHR) to hypertonic saline were also measured to assess whether these additional objective parameters might aid in determining asthma control; 54.5% of subjects had adequately controlled asthma; 50.4% of all subjects reported inhaled corticosteroid use in the preceding 12 months; however, only 22.3% reported regular use. Although BHR and median eosinophil numbers were significantly higher in the inadequately controlled asthmatics, BHR and sputum eosinophilia had poor sensitivity for detecting inadequate asthma control.
通过哮喘症状、肺功能以及哮喘药物使用情况来定义的哮喘控制情况，在123名青少年哮喘患者中进行了评估。还测量了痰液嗜酸性粒细胞（≥2.5%嗜酸性粒细胞）以及对高渗盐水的支气管高反应性（BHR），以评估这些额外的客观参数是否有助于确定哮喘控制情况；54.5%的受试者哮喘得到了充分控制；所有受试者中有50.4%报告在过去12个月内使用过吸入性糖皮质激素；然而，只有22.3%报告为规律使用。虽然在控制不佳的哮喘患者中BHR和嗜酸性粒细胞中位数显著更高，但BHR和痰液嗜酸性粒细胞在检测哮喘控制不佳方面的敏感性较差。
