Abrams R M, Gerhardt K J, Burchfield D J
University of Florida, College of Medicine, Dept. of Obstetrics and Gynecology, Gainesville 32610.
J Dev Physiol. 1991 May;15(5):283-8.
Local cerebral blood flow in four near term fetal sheep was evaluated continuously before and after natural alternations in fetal behavioral state. Measurements were made in fetuses several days following an aseptic surgery to place electrodes for behavioral state recordings as well as heated and reference thermojunctions in cortical and subcortical tissue. These thermojunctions were used to qualitatively assess local cerebral blood flow. The time of transition between rapid eye movement sleep (REMS) and non-rapid eye movement sleep (NREMS) was based on visual inspection of strip chart recordings of electrocortical, electroocular, and neck electromyographic activity and application of published criteria for their assessment. To confirm that transition had occurred, the amplitude of the spectrum of the electrocorticogram in one-third octave bands centered around 1 Hz and 20 Hz was measured before and after the transition point. Mean cerebral blood flow rose significantly by 24 s (P less than 0.05) after the transition from NREMS to REMS and fell by 12 s after the transition from REMS to NREMS (P less than 0.05).
在近足月的四只胎羊中，在胎儿行为状态自然交替前后连续评估局部脑血流量。在无菌手术后数天对胎儿进行测量，手术目的是放置电极以记录行为状态，并在皮质和皮质下组织中放置加热和参考热电偶。这些热电偶用于定性评估局部脑血流量。快速眼动睡眠（REMS）和非快速眼动睡眠（NREMS）之间的转换时间基于对脑电图、眼电图和颈部肌电图活动的带状图表记录的目视检查以及应用已发表的评估标准。为了确认转换已经发生，在转换点前后测量以1Hz和20Hz为中心的三分之一倍频程带的脑电图频谱幅度。从NREMS转换到REMS后，平均脑血流量在24秒时显著上升（P小于0.05），从REMS转换到NREMS后下降12秒（P小于0.05）。
