Abrams R M, Post J C, Burchfield D J, Gomez K J, Hutchison A A, Conlon M
Department of Obstetrics and Gynecology, University of Florida, Gainesville.
Am J Obstet Gynecol. 1990 Jan;162(1):278-81. doi: 10.1016/0002-9378(90)90865-5.
Behavioral state-induced changes in fetal cerebral blood flow were continuously monitored with a simple thermal dilution method. Thermojunctions were heated 1.5 degrees C above reference thermojunctions implanted contralaterally in various cerebral cortical and subcortical structures of four near-term fetal sheep. Temperature difference in rapid-eye-movement sleep was lower than in non-rapid-eye-movement sleep (p = 0.014), reflecting convective heat loss from increased blood flow. Temperature difference also varied significantly with the locus of placement in the brain (p = 0.003), reflecting, in part, regional differences in cerebral blood flow. The thermocouple method gives qualitative, continuous information on local cerebral blood flow that could be useful in monitoring the vascular response to changing functional activity during prenatal brain development.
采用一种简单的热稀释法持续监测行为状态引起的胎儿脑血流变化。将热电偶加热至比植入对侧四个近足月胎羊不同大脑皮质和皮质下结构的参考热电偶高1.5摄氏度。快速眼动睡眠时的温差低于非快速眼动睡眠时（p = 0.014），这反映了因血流增加导致的对流热损失。温差也随大脑中放置部位的不同而有显著变化（p = 0.003），这部分反映了脑血流的区域差异。热电偶法可提供关于局部脑血流的定性、连续信息，这对于监测产前脑发育过程中血管对功能活动变化的反应可能有用。
