Regio- and stereoselective cross-coupling of substituted olefins and imines. A convergent stereoselective synthesis of saturated 1,5-amino-alcohols and substituted piperidines.
作者信息
Takahashi Masayuki, Micalizio Glenn C
机构信息
Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.
出版信息
J Am Chem Soc. 2007 Jun 20;129(24):7514-6. doi: 10.1021/ja071974v. Epub 2007 May 26.
Abstract
摘要
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A site- and stereoselective intermolecular alkene-alkyne coupling process.一种位点和立体选择性的分子间烯烃-炔烃偶联过程。
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An alkoxide-directed carbometalation of internal alkynes.醇盐导向的内炔烃碳金属化反应。
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Hydrogen-mediated reductive coupling of conjugated alkynes with ethyl (N-Sulfinyl)iminoacetates: synthesis of unnatural alpha-amino acids via rhodium-catalyzed C-C bond forming hydrogenation.氢介导的共轭炔烃与（N-亚磺酰基）亚氨基乙酸乙酯的还原偶联：通过铑催化的碳-碳键形成氢化反应合成非天然α-氨基酸
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Highly stereo- and regioselective ni-catalyzed homoallylation of aldimines with conjugated dienes promoted by diethylzinc.在二乙基锌促进下，镍催化的醛亚胺与共轭二烯的高度立体和区域选择性高烯丙基化反应。
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Asymmetric catalytic coupling of organoboranes, alkynes, and imines with a removable (trialkylsilyloxy)ethyl group--direct access to enantiomerically pure primary allylic amines.具有可脱除（三烷基硅氧基）乙基的有机硼烷、炔烃和亚胺的不对称催化偶联——直接获得对映体纯的伯烯丙基胺。
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Asymmetric synthesis of allyl- and alpha-allenylamines from chiral imines and alkynes via (eta(2)-imine)Ti(O-i-Pr)2 complexes.
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Catalytic three-component coupling of alkynes, imines, and organoboron reagents.炔烃、亚胺和有机硼试剂的催化三组分偶联反应。
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