Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
Angew Chem Int Ed Engl. 2013 May 10;52(20):5368-71. doi: 10.1002/anie.201301741. Epub 2013 Apr 19.
An enantioselective rhodium (I) catalyzed [2+2+2] cycloaddition with a cleavable tether has been developed. The reaction proceeds with a variety of alkyne substrates in good yield and high enantioselectivity. Upon reduction of the vinylogous amide in high diastereoselectivity (>19:1) and cleavage of the tether, -methylpiperidine products with functional group handles can be accessed.
已开发出一种对映选择性铑(I)催化的带有可裂解键的[2+2+2]环加成反应。该反应以多种炔烃底物进行,产率高,对映选择性好。在高非对映选择性 (>19:1)还原乙烯基酰胺并裂解键后,可以得到具有官能团的 - 甲基哌啶产物。