Grifo James A, Flisser Eric, Adler Alexis, McCaffrey Caroline, Krey Lewis C, Licciardi Frederick, Noyes Nicole, Kump Lisa M, Berkeley Alan S
New York University Fertility Center, New York University School of Medicine, New York, New York 10016, USA.
Fertil Steril. 2007 Aug;88(2):294-300. doi: 10.1016/j.fertnstert.2006.10.005. Epub 2007 May 25.
To assess whether the use of extended embryo culture can reduce the incidence of high-order multiple gestations, a retrospective analysis of 7,418 fresh ETs performed in a university-based IVF clinic from 1997-2003 was conducted, comparing program results before and after institution of a protocol to select patients for extended culture of in vitro fertilized embryos. The incidence of triplet pregnancies was significantly reduced in patients at highest risk for high-order multiple gestations, i.e., those at <35 years of age (16.8% versus 6.8%), those at 35-37 years of age (13.0% versus 5.6%), and recipients of donated oocytes (11.2% versus 4.5%).
为评估延长胚胎培养的使用是否可降低高阶多胎妊娠的发生率，对1997年至2003年在一家大学附属医院的体外受精诊所进行的7418例新鲜胚胎移植进行了回顾性分析，比较了在制定选择体外受精胚胎进行延长培养患者的方案前后的项目结果。在高阶多胎妊娠风险最高的患者中，即年龄小于35岁的患者（16.8%对6.8%）、35至37岁的患者（13.0%对5.6%）以及接受捐赠卵母细胞的患者（11.2%对4.5%）中，三胎妊娠的发生率显著降低。
