在试管婴儿周期的头 35 天中，老年甲状腺功能正常的不孕妇女自身免疫性甲状腺疾病的影响。
Effect of autoimmune thyroid disease in older euthyroid infertile woman during the first 35 days of an IVF cycle.
机构信息
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, New York University Fertility Center, New York, New York, USA.
出版信息
Fertil Steril. 2011 Mar 1;95(3):1178-81. doi: 10.1016/j.fertnstert.2010.09.053. Epub 2010 Nov 3.
Abstract
In this case-control study of euthyroid first-cycle IVF patients ≥ 38 years old with singleton baby, miscarriage, biochemical pregnancy, and no pregnancy outcomes from 2005-2008, we assayed frozen serum for autoimmune thyroid disease (AITD) and thyroid function at cycle start, trigger, and 4 and 5 weeks' gestation. AITD prevalence in older infertile women was similar across clinical outcomes, and although AITD was associated with a higher baseline TSH, TSH remained within acceptable ranges, suggesting that T(4) supplementation may not affect maternal outcomes in older euthyroid AITD patients through 5 weeks gestation.
摘要
在这项对 2005 年至 2008 年间年龄≥38 岁的甲状腺功能正常的首周期 IVF 患者（单胎婴儿、流产、生化妊娠和无妊娠结局）的病例对照研究中，我们在周期开始、扳机和 4 周及 5 周妊娠时检测了冷冻血清中的自身免疫性甲状腺疾病（AITD）和甲状腺功能。在不同临床结局中，高龄不孕女性的 AITD 患病率相似，尽管 AITD 与较高的基础 TSH 相关，但 TSH 仍处于可接受范围内，这表明在 5 周妊娠前，T4 补充可能不会影响高龄甲状腺功能正常的 AITD 患者的母婴结局。
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