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Pyrazolone methylamino piperidine derivatives as novel CCR3 antagonists.

作者信息

Pégurier Cécile, Collart Philippe, Danhaive Pierre, Defays Sabine, Gillard Michel, Gilson Frédéric, Kogej Thierry, Pasau Patrick, Van Houtvin Nathalie, Van Thuyne Marc, van Keulen BerendJan

机构信息

UCB Pharma SA, R&D, Chemin du Foriest, B-1420 Braine-L'Alleud, Belgium.

出版信息

Bioorg Med Chem Lett. 2007 Aug 1;17(15):4228-31. doi: 10.1016/j.bmcl.2007.05.035. Epub 2007 May 17.

DOI:10.1016/j.bmcl.2007.05.035
PMID:17532633
Abstract

The discovery and optimization of a novel class of potent CCR3 antagonists is described. Details of synthesis and SAR are given together with some ADME properties of selected compounds. An optimal balance between activities, physicochemical properties, and in vitro metabolic stability was reached by the proper choice of substituents.

摘要

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