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意大利睡眠专家和初级保健医生制定的一般实践中的失眠共识报告。

Insomnia in general practice : a consensus report produced by sleep specialists and primary-care physicians in Italy.

机构信息

Department of Neurology, Sleep Disorders Centre, University of Parma, Parma, Italy.

出版信息

Clin Drug Investig. 2005;25(12):745-64. doi: 10.2165/00044011-200525120-00002.

Abstract

Insomnia is an extremely common condition with major social and economic consequences worldwide. Two large epidemiological studies (Morfeo 1 and Morfeo 2) recently performed in Italy provided much-needed novel data on the impact of insomnia in patients whose primary healthcare is provided by general practitioners (GPs). These studies found that insomnia is managed relatively well by GPs in Italy, although diagnosis and treatment can be compromised because of the lack of standardised criteria. Although a number of consensus reports on insomnia have been published, these are mainly highly specific documents that are difficult to implement in general practice. To address this, a consensus group involving 695 GPs and over 60 specialists from the Italian Association of Sleep Medicine was established. The major objectives of the consensus study were to establish basic knowledge for the diagnosis and treatment of insomnia, and to produce guidelines for the management of insomnia by GPs. This is the first time that GPs have been directly involved in producing insomnia guidelines of this type, and this approach reflects their pivotal role in the diagnosis and management of this condition. Participants were carefully selected to ensure adequate representation of sleep specialists and GPs, with the group being headed by a steering committee and an advisory board. Guideline statements were selected following careful literature review and were voted on using formalised consensus procedures. This review describes current views on the diagnosis and management of insomnia from the perspective of the GP. In addition, the results of the consensus study are presented. They include recognition of the following principles: (i) insomnia is a genuine pathology that must be appropriately diagnosed and treated; (ii) when concomitant pathologies are present, additional significance should be given to treatment of insomnia since it can influence prognosis of coexistent disorders; (iii) appropriate treatment should consider the cause of insomnia as well as the characteristics of available pharmacological agents; (iv) with regard to hypnotic drugs, preference should be given to medications with a short half-life in order to limit residual effects; (v) non-benzodiazepine hypnotics are preferred to classic benzodiazepines as they have higher selectivity and present a lower risk of undesirable effects; (vi) tablets are preferable to liquid preparations as they are less likely to lead to dependence and to overdosing by the patient; and (vi) once treatment has been initiated, insomnia patients should be carefully followed up. These statements provide much needed criteria for better management of insomnia by GPs in Italy.

摘要

失眠是一种极其常见的病症,在全球范围内会带来重大的社会和经济后果。最近在意大利进行的两项大型流行病学研究(Morfeo 1 和 Morfeo 2)提供了急需的新数据,说明初级保健医生(全科医生)所治疗的失眠患者的影响。这些研究发现,意大利的全科医生对失眠的管理相对较好,尽管由于缺乏标准化标准,可能会影响诊断和治疗。尽管已经发表了许多关于失眠的共识报告,但这些报告主要是高度具体的文件,在全科实践中难以实施。为了解决这个问题,成立了一个由 695 名全科医生和来自意大利睡眠医学协会的 60 多名专家组成的共识小组。共识研究的主要目标是为失眠的诊断和治疗建立基本知识,并为全科医生管理失眠制定指南。这是全科医生首次直接参与编写此类失眠指南,这种方法反映了他们在诊断和管理这种疾病中的关键作用。参与者经过精心挑选,以确保睡眠专家和全科医生的充分代表性,该小组由一个指导委员会和一个顾问委员会领导。指南陈述是在仔细审查文献后选择的,并使用正式的共识程序进行投票。本综述从全科医生的角度描述了当前对失眠的诊断和管理的看法。此外,还介绍了共识研究的结果。它们包括认识到以下原则:(i)失眠是一种真正的病理,必须进行适当的诊断和治疗;(ii)当存在伴随的病理时,应更加重视失眠的治疗,因为它会影响共存疾病的预后;(iii)适当的治疗应考虑失眠的原因以及现有药物的特点;(iv)关于催眠药物,应优先选择半衰期短的药物,以限制残留作用;(v)非苯二氮䓬类催眠药优于经典苯二氮䓬类药物,因为它们具有更高的选择性,并且不良作用的风险较低;(vi)片剂优于液体制剂,因为它们不太可能导致依赖和患者过量用药;(vi)一旦开始治疗,就应仔细随访失眠患者。这些陈述为意大利的全科医生更好地管理失眠提供了急需的标准。

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