Ronco Pierre, Lelongt Brigitte, Piedagnel Rémi, Chatziantoniou Christos
INSERM Unit 702, and Université Pierre et Marie Curie, Paris, France.
Semin Nephrol. 2007 May;27(3):352-62. doi: 10.1016/j.semnephrol.2007.02.006.
Matrix metalloproteinases (MMPs) have pleiotropic enzymatic actions that go far beyond degradation of extracellular matrix. Both the multiplicity of their targets and the complexity of their regulation account for a variety of biological effects. In renal diseases, MMP effects may be different and/or opposite during the different phases of the pathology evolution. The major challenge with future therapeutic interventions using MMP inhibitors remains how to accomplish temporal and spatial control of their activity without flipping the coin.
基质金属蛋白酶（MMPs）具有多效性酶促作用，其作用远不止于降解细胞外基质。其靶标的多样性和调节的复杂性共同导致了多种生物学效应。在肾脏疾病中，MMPs在病理演变的不同阶段可能产生不同和/或相反的作用。未来使用MMP抑制剂进行治疗干预的主要挑战仍然是如何在不产生不良影响的情况下实现对其活性的时空控制。
