Yadav Dhiraj, Papachristou Georgios I, Whitcomb David C
Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Gastroenterol Clin North Am. 2007 Jun;36(2):219-38, vii. doi: 10.1016/j.gtc.2007.03.005.
Only a small proportion of heavy drinking individuals develop pancreatitis. The environmental and host cofactors shown to have an association with alcoholic pancreatitis are smoking and race. The known genetic variations and polymorphisms do not seem to play an important role in alcoholic pancreatitis. Newer developments in the understanding of complex disorders allow clinicians to understand better the role of cofactors and interactions between known and yet unknown environmental and genetic factors in causing alcoholic pancreatitis.
只有一小部分酗酒者会患上胰腺炎。已表明与酒精性胰腺炎相关的环境和宿主辅助因素是吸烟和种族。已知的基因变异和多态性似乎在酒精性胰腺炎中并不起重要作用。对复杂疾病认识的新进展使临床医生能够更好地理解辅助因素以及已知和未知环境与基因因素之间的相互作用在导致酒精性胰腺炎中所起的作用。