Hamdi Hanan, Soleymani Samaneh, Zargaran Arman
Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.
School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Caspian J Intern Med. 2022 Spring;13(2):431-435. doi: 10.22088/cjim.13.2.431.
Historical evidence revealed that alcoholic beverages have been produced, used and abused thousands of years before the discovery of alcohol by Rhazes for medical purposes. Alcohol-induced liver disease (e.g., steatosis, steatohepatitis, fibrosis and cirrhosis) is one of the most prevalent causes of chronic liver disease all over the world. This study aims to find the early report of this complication in an ancient Persian historical text.
In this study, the book of , a Zoroastrian manuscript on wisdom which was written in the late Sassanid Empire (224-637 CE) is reviewed.
However, the concept of alcohol hepatotoxicity as one of the most important complications of alcoholism is a new terminology, by researching historical documents it can be found that one of the oldest reports of benefits and disadvantages of drinking wine focusing on liver complications is mentioned in the book of .
Description of the liver disease and damage caused by excessive alcohol consumption in this valuable book can be considered as the early report of hepatotoxicity of alcoholic beverages in the medical history.
历史证据表明，在拉齐斯发现酒精用于医疗目的之前的数千年，酒精饮料就已被生产、使用和滥用。酒精性肝病（如脂肪变性、脂肪性肝炎、纤维化和肝硬化）是全球慢性肝病最常见的病因之一。本研究旨在在一份古代波斯历史文献中找到关于这一并发症的早期报告。
在本研究中，对一部在萨珊帝国晚期（公元224 - 637年）撰写的关于智慧的琐罗亚斯德教手稿《 》进行了审阅。
然而，酒精肝毒性作为酗酒最重要的并发症之一是一个新术语，通过研究历史文献可以发现，《 》中提到了关于饮酒利弊且着重于肝脏并发症的最古老报告之一。
这本珍贵书籍中对过量饮酒导致的肝脏疾病和损害的描述可被视为医学史上酒精饮料肝毒性的早期报告。
