胰腺内分泌肿瘤

Pancreatic endocrine tumors.

作者信息

Jani Niraj, Moser A James, Khalid Asif

机构信息

The Department of Medicine, The University of Pittsburgh Medical Center, 200 Lothrop Street, Mezz Level C, PUH, Pittsburgh, PA, USA.

出版信息

Gastroenterol Clin North Am. 2007 Jun;36(2):431-9, x-xi. doi: 10.1016/j.gtc.2007.03.002.

DOI:10.1016/j.gtc.2007.03.002

PMID:17533088

Abstract

Incidental, nonfunctional pancreatic endocrine tumors (PET) are observed with increasing frequency. Most are insulinomas. Endoscopic ultrasound with fine-needle aspiration plays a significant role in the localization and tissue diagnosis of PET. Establishing PET behavior as aggressive or indolent remains challenging especially preoperatively. Newer techniques including DNA and micro-RNA analysis may play a role in this arena. Small benign PET may be enucleated or removed laparoscopically. Surgery is the mainstay of treating advanced disease including those with metastases and Zollinger-Ellison syndrome. The management of multiple endocrine neoplasia type 1 continues to be a challenge, including treating symptoms, targeted resections, and close observation. Diagnosis, management, and prognostication of PET are under evolution and a number of changes in these fronts are anticipated.

摘要

偶然发现的无功能胰腺内分泌肿瘤（PET）的检出率日益增加。其中大多数是胰岛素瘤。内镜超声引导下细针穿刺活检在PET的定位和组织诊断中发挥着重要作用。术前确定PET的侵袭性或惰性行为仍然具有挑战性。包括DNA和微小RNA分析在内的新技术可能在这一领域发挥作用。小型良性PET可通过剜除术或腹腔镜手术切除。手术是治疗晚期疾病（包括有转移的疾病和佐林格-埃利森综合征）的主要方法。1型多发性内分泌腺瘤病的管理仍然是一项挑战，包括症状治疗、靶向切除和密切观察。PET的诊断、管理和预后评估仍在不断发展，预计在这些方面会有许多变化。