Stamatakos M, Safioleas C, Tsaknaki S, Safioleas P, Iannescu R, Safioleas M
4h Department of Surgery, University of Athens, School of Medicine, Attikon General Hospital, Athens, Greece.
Chirurgia (Bucur). 2009 Nov-Dec;104(6):669-73.
Insulinomas are functional endocrine tumors originating from the pancreatic b-cells. In 1902 Nicholls described the first adenoma of pancreatic islets, while the first insulinoma was described in 1927 in Mayo Clinic, which was dissected two years later in 1929 in Toronto. The first enucleation of insulinoma took place in a St. Jouis hospital in 1931, and after four years, in 1935, Whipple described the classic diagnostic triad: symptoms of fasting hypoglycemia or fatigue, blood glucose levels under 50 mg/dl and disappearance of symptoms after glucose administration.
胰岛素瘤是起源于胰腺β细胞的功能性内分泌肿瘤。1902年，尼科尔斯描述了首例胰岛腺瘤，而首例胰岛素瘤于1927年在梅奥诊所被发现，并于两年后的1929年在多伦多进行了解剖。1931年，首例胰岛素瘤摘除手术在圣路易斯的一家医院进行，四年后的1935年，惠普尔描述了经典的诊断三联征：空腹低血糖或疲劳症状、血糖水平低于50mg/dl以及给予葡萄糖后症状消失。
