Levy Daniel, Hwang Shih-Jen, Kayalar Atilla, Benjamin Emelia J, Vasan Ramachandran S, Parise Helen, Larson Martin G, Wang Thomas J, Selhub Jacob, Jacques Paul F, Vita Joseph A, Keyes Michelle J, Mitchell Gary F
NHLBI Framingham Heart Study, Framingham, Mass, USA.
Circulation. 2007 Jun 19;115(24):3079-85. doi: 10.1161/CIRCULATIONAHA.106.652842. Epub 2007 May 28.
Increased arterial stiffness and higher plasma natriuretic peptide and homocysteine levels are associated with elevated risk for cardiovascular disease. Little is known about the relations of natriuretic peptides and homocysteine to arterial wall stiffness in the community.
We assessed the relations of plasma N-terminal atrial natriuretic peptide, B-type natriuretic peptide, adrenomedullin, and homocysteine concentrations to arterial stiffness in participants in the Framingham Heart Study. Central pulse pressure, forward pressure wave, reflected pressure wave, carotid-femoral pulse wave velocity, and carotid-radial pulse wave velocity were assessed by tonometry in 1962 participants (mean age, 61 years; 56% women) in the Framingham Heart Study. Central systolic and diastolic blood pressures were 123/75 mm Hg in men and 119/66 mm Hg in women. After adjustment for age and clinical covariates, N-terminal atrial natriuretic peptide and B-type natriuretic peptide were associated with carotid-femoral pulse wave velocity (men: partial correlation, 0.069, P = 0.043 and r = 0.115, P < or = 0.001, respectively; women: r = -0.063, P = 0.037 and r = -0.062, P = 0.040), and carotid-radial pulse wave velocity (men: r = -0.090, P = 0.009 and r = -0.083, P < or = 0.015; women: r = -0.140, P < or = 0.001 and r = -0.104, P = 0.001, respectively). In men, N-terminal atrial natriuretic peptide and B-type natriuretic peptide also were associated with forward and reflected wave and carotid pulse pressure. In men, adrenomedullin was associated with mean arterial pressure (r = 0.089, P = 0.009), and homocysteine was associated with carotid-femoral pulse wave velocity (r = 0.072, P = 0.036), forward pressure (r = 0.079, P = 0.02), and central pulse pressure (r = 0.072, P = 0.035). Interaction tests indicated sex differences in the relations of several biomarkers to measures of arterial stiffness.
Plasma natriuretic peptide, adrenomedullin, and homocysteine levels are associated with alterations in conduit vessel properties that differ in men and women.
动脉僵硬度增加、血浆利钠肽和同型半胱氨酸水平升高与心血管疾病风险升高相关。关于社区中利钠肽和同型半胱氨酸与动脉壁僵硬度的关系知之甚少。
我们在弗雷明汉心脏研究的参与者中评估了血浆N末端心房利钠肽、B型利钠肽、肾上腺髓质素和同型半胱氨酸浓度与动脉僵硬度的关系。通过眼压测量法对弗雷明汉心脏研究中的1962名参与者（平均年龄61岁；56%为女性）的中心脉压、前向压力波、反射压力波、颈动脉-股动脉脉搏波速度和颈动脉-桡动脉脉搏波速度进行了评估。男性的中心收缩压和舒张压分别为123/75 mmHg，女性为119/66 mmHg。在调整年龄和临床协变量后，N末端心房利钠肽和B型利钠肽与颈动脉-股动脉脉搏波速度相关（男性：偏相关系数分别为0.069，P = 0.043和r = 0.115，P≤0.001；女性：r = -0.063，P = 0.037和r = -0.062，P = 0.040），以及与颈动脉-桡动脉脉搏波速度相关（男性：r = -0.090，P = 0.009和r = -0.083，P≤0.015；女性：r = -0.140，P≤0.001和r = -0.104，P = 0.001）。在男性中，N末端心房利钠肽和B型利钠肽也与前向波和反射波以及颈动脉脉压相关。在男性中，肾上腺髓质素与平均动脉压相关（r = 0.069，P = 0.043），同型半胱氨酸与颈动脉-股动脉脉搏波速度相关（r = 0.072，P = 0.036）、前向压力（r = 0.079，P = 0.02）和中心脉压相关（r = 0.072，P = 0.035）。交互作用测试表明，几种生物标志物与动脉僵硬度测量指标之间的关系存在性别差异。
血浆利钠肽、肾上腺髓质素和同型半胱氨酸水平与男女不同的传导血管特性改变相关。
