Department of Cardiology, Peking University First Hospital, Beijing, China.
Renal Division, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Guangzhou, China.
Sci Rep. 2017 Jul 24;7(1):6316. doi: 10.1038/s41598-017-06611-3.
Previous studies indicated that homocysteine (Hcy) is associated with higher peripheral systolic blood pressure (pSBP). There have been few data on the relationship between Hcy and central SBP (cSBP). A total of 4,364 Chinese subjects from the Shijingshan community in Beijing were included. cSBP and pSBP were measured with an Omron HEM-9000AI device. Subjects were 57.20 ± 8.9 years old, 37.9% were male. The median of Hcy was 11.96 μmol/L. The mean of cSBP and pSBP was 129.94 ± 18.03 mmHg and 133.25 ± 18.58 mmHg. lnHcy was associated with cSBP (adjusted β = 2.17, SE = 0.80, P = 0.007) and pSBP (adjusted β = 2.42, SE = 0.75, P = 0.001). With increasing Hcy, there were enhanced correlations of Hcy with pSBP and cSBP (p for trend between quartiles <0.01). Using Q1 for reference, the Q4 was associated with cSBP (adjusted β = 1.77, SE = 0.89, P = 0.047) and pSBP (adjusted β = 2.15, SE = 0.84, P = 0.011). The correlations were more significant in non-obese subjects than in obese subjects (cSBP: β = 4.30 vs 0.46, pSBP: β = 5.04 vs 1.18, P for interaction <0.001). Our study showed that Hcy was associated with higher cSBP and pSBP, especially in non-obese subjects.
先前的研究表明，同型半胱氨酸（Hcy）与外周收缩压（pSBP）升高有关。但关于 Hcy 与中心收缩压（cSBP）之间的关系的数据较少。本研究共纳入北京石景山区社区的 4364 名中国受试者。使用欧姆龙 HEM-9000AI 设备测量 cSBP 和 pSBP。受试者年龄为 57.20±8.9 岁，37.9%为男性。Hcy 的中位数为 11.96μmol/L。cSBP 和 pSBP 的平均值分别为 129.94±18.03mmHg 和 133.25±18.58mmHg。lnHcy 与 cSBP（调整后β=2.17，SE=0.80，P=0.007）和 pSBP（调整后β=2.42，SE=0.75，P=0.001）相关。随着 Hcy 的增加，Hcy 与 pSBP 和 cSBP 的相关性增强（四分位间距之间的趋势 P<0.01）。以 Q1 为参照，Q4 与 cSBP（调整后β=1.77，SE=0.89，P=0.047）和 pSBP（调整后β=2.15，SE=0.84，P=0.011）相关。在非肥胖受试者中，这种相关性比在肥胖受试者中更为显著（cSBP：β=4.30 与 0.46，pSBP：β=5.04 与 1.18，P 交互<0.001）。本研究表明，Hcy 与较高的 cSBP 和 pSBP 相关，尤其是在非肥胖受试者中。
