Fazely F, Haseltine W A, Rodger R F, Ruprecht R M
Laboratory of Viral Pathogenesis, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
J Acquir Immune Defic Syndr (1988). 1991;4(11):1093-7.
Presently, no information is available regarding the efficacy of chemoprophylaxis in controlled human trials following accidental exposure to the human immunodeficiency virus (HIV). Using the closely related simian immunodeficiency virus (SIV) in rhesus monkeys, which develop a disease closely resembling human AIDS, we tested the efficacy of either single-agent 3'-azido-3'-deoxythymidine (ZDV) or the combination of ZDV plus recombinant human interferon-alpha (IFN-alpha). Treatment was started 3 h following inoculation of a high dose of SIV and continued for 21 days. SIV-inoculated control animals remained untreated. Virus was recovered from all monkeys on day 8, and by week 7 all had seroconverted. In contrast to monkeys treated with ZDV alone, animals given combination therapy had lower levels of p27 gag antigen compared to untreated controls on day 8 (p = 0.043). We conclude that neither treatment regimen could prevent infection after high-dose virus exposure; however, combination therapy may have depressed the level of virus replication more effectively than ZDV alone.
目前，关于意外暴露于人类免疫缺陷病毒（HIV）后进行化学预防在人体对照试验中的疗效尚无可用信息。我们利用恒河猴身上与HIV密切相关的猿猴免疫缺陷病毒（SIV）进行研究，恒河猴会患上与人类艾滋病极为相似的疾病，我们测试了单药3'-叠氮-3'-脱氧胸苷（ZDV）或ZDV加重组人干扰素-α（IFN-α）联合用药的疗效。在接种高剂量SIV后3小时开始治疗，并持续21天。接种SIV的对照动物未接受治疗。在第8天从所有猴子身上都检测到了病毒，到第7周时所有猴子都发生了血清转化。与仅接受ZDV治疗的猴子相比，接受联合治疗的动物在第8天时p27 gag抗原水平低于未治疗的对照动物（p = 0.043）。我们得出结论，两种治疗方案均不能预防高剂量病毒暴露后的感染；然而，联合治疗可能比单独使用ZDV更有效地抑制了病毒复制水平。
