Martin L N, Murphey-Corb M, Soike K F, Davison-Fairburn B, Baskin G B
Tulane Regional Primate Research Center, Tulane University, Covington, Louisiana.
J Infect Dis. 1993 Oct;168(4):825-35. doi: 10.1093/infdis/168.4.825.
The effects of initiating treatment with 3'-azido-3'-deoxythymidine (zidovudine) at different times after inoculation of simian immunodeficiency virus (SIV) were investigated in rhesus monkeys. Zidovudine treatments of 100 mg/kg/day (25 mg/kg, subcutaneously every 6 h) were initiated 1, 8, 24, or 72 h after intravenous inoculation of 10 ID50 of SIV. Treatments continued for 28 days, and results were compared with those of saline-treated controls. Serum infectious virus titers 14 days after inoculation (AI) significantly decreased after treatment initiation 1, 8, or 24 h AI. Titers were correlated with the time treatment was initiated. Treatments initiated 1-72 h AI prevented the establishment of persistent SIV antigenemia; greater effects were observed with earlier initiation of treatment. Treatments initiated 1-8 h AI resulted in decreased levels of viral antigenemia 14 days AI and delayed decreases in CD4+CD29+ blood lymphocytes. Earlier treatment initiation resulted in delayed recurrence of antigenemia, with a tendency for longer survival. Early initiation of treatment may be important for limiting initial viral replication and dissemination in cases of known exposure.
在恒河猴中研究了在接种猿猴免疫缺陷病毒（SIV）后不同时间开始用3'-叠氮基-3'-脱氧胸苷（齐多夫定）进行治疗的效果。在静脉注射10个半数感染剂量（ID50）的SIV后1、8、24或72小时开始用齐多夫定以100mg/kg/天（25mg/kg，每6小时皮下注射一次）进行治疗。治疗持续28天，并将结果与盐水治疗的对照组进行比较。接种后14天（AI）的血清感染性病毒滴度在接种后1、8或24小时开始治疗后显著降低。滴度与开始治疗的时间相关。在接种后1 - 72小时开始治疗可预防持续性SIV抗原血症的建立；治疗开始越早，效果越明显。在接种后1 - 8小时开始治疗导致接种后14天病毒抗原血症水平降低，并延迟了CD4 + CD29 +血液淋巴细胞的减少。更早开始治疗导致抗原血症复发延迟，有生存时间更长的趋势。在已知暴露的情况下，尽早开始治疗对于限制初始病毒复制和传播可能很重要。
