Adelman A S, Groves F D, O'Rourke K, Sinha D, Hulsey T C, Lawson A B, Wartenberg D, Hoel D G
Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, 135 Cannon Street, Charleston, SC 29425, USA.
Br J Cancer. 2007 Jul 2;97(1):140-4. doi: 10.1038/sj.bjc.6603793. Epub 2007 May 29.
We conducted an ecological analysis of childhood acute lymphoblastic leukaemia-incidence data from children <or=5 years old during 1992-1998 from the Surveillance, Epidemiology, and End Results Program in 200 counties and Hawaii. The response variable was the count of cases in each county race-sex stratum, examined in relation to data from the United States Census and the United States Department of Agriculture. The final models for both sexes included race, proportion moved during 1985-1990, and proportion of households with income >or=$5000 as potential predictors. Incidence was lower among black boys (rate ratio (RR)=0.5) and black girls (RR=0.4) than among other children of the same sex; no other significant racial differences were detected. Incidence was elevated among males (but not females) residing in counties where >or=50% of the population relocated (RR=1.5) and among females (but not males) residing in counties where <6% of the households had incomes <$5000 (RR=1.5). These sex differences in risk factors were unexpected.
我们对1992 - 1998年期间来自200个县及夏威夷的监测、流行病学和最终结果计划中5岁及以下儿童的儿童急性淋巴细胞白血病发病率数据进行了生态分析。反应变量是每个县种族 - 性别分层中的病例数，并与美国人口普查和美国农业部的数据相关联进行考察。两性的最终模型均纳入了种族、1985 - 1990年期间迁移的比例以及收入高于或等于5000美元的家庭比例作为潜在预测因素。黑人男孩（率比（RR）=0.5）和黑人女孩（RR = 0.4）的发病率低于同性别的其他儿童；未检测到其他显著的种族差异。居住在人口迁移比例≥50%的县的男性（而非女性）（RR = 1.5）以及居住在家庭收入低于5000美元的家庭比例<6%的县的女性（而非男性）（RR = 1.5）发病率升高。这些危险因素中的性别差异出乎意料。
