Slingerland L I, Robben J H, van Haeften T W, Kooistra H S, Rijnberk A
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Horm Metab Res. 2007 May;39(5):341-6. doi: 10.1055/s-2007-976541.
A hyperglycemic clamp (HGC) was developed for use in conscious cats. In 21 healthy, normal glucose tolerant cats glucose disposal rate (M), insulin sensitivity (ISI (HGC)), and beta-cell response (I) at arterial plasma glucose of 9 mmol.l (-1) were measured. The HGC was tolerated well and steady state glucose infusion was achieved. Compared to values reported for humans, M values for the cats were low, which appeared to relate to both a low ISI (HGC) and a low I. HGC measures correlated with fasting plasma glucose and insulin concentrations as well as with their HOMA (homeostasis model assessment) and QUICKI (quantitative insulin sensitivity check index) counterparts. Also, I and ISI (HGC) correlated with their counterparts derived from intravenous glucose tolerance tests. In conclusion, this is the first report of hyperglycemic glucose clamping in cats. The procedure (HGC) allows for measurements of glucose disposal, beta-cell response and insulin sensitivity. Compared to human data, both insulin sensitivity and insulin secretion appeared to be low in cats. This is compatible with the carnivorous nature of this species, for which insulin resistance would be advantageous during periods of restricted food availability.
为用于清醒猫而开发了一种高血糖钳夹技术（HGC）。对21只健康、糖耐量正常的猫在动脉血浆葡萄糖浓度为9 mmol·l⁻¹时的葡萄糖处置率（M）、胰岛素敏感性（ISI（HGC））和β细胞反应（I）进行了测量。HGC耐受性良好，实现了稳态葡萄糖输注。与报道的人类值相比，猫的M值较低，这似乎与低ISI（HGC）和低I均有关。HGC测量值与空腹血浆葡萄糖和胰岛素浓度以及它们的HOMA（稳态模型评估）和QUICKI（定量胰岛素敏感性检查指数）对应值相关。此外，I和ISI（HGC）与静脉葡萄糖耐量试验得出的对应值相关。总之，这是关于猫高血糖钳夹技术的首次报告。该程序（HGC）允许测量葡萄糖处置、β细胞反应和胰岛素敏感性。与人类数据相比，猫的胰岛素敏感性和胰岛素分泌似乎都较低。这与该物种的肉食性本质相符，对于这种物种而言，在食物供应受限期间胰岛素抵抗可能是有利的。
