Rasool M, Sabina E P
School of Bio-engineering and Biosciences, Vellore Institute of Technology, Deemed University, Vellore 632 014, Tamil Nadu, India.
Phytother Res. 2007 Sep;21(9):889-94. doi: 10.1002/ptr.2183.
In the present study, attempts have been made to evaluate the antiarthritic effect of the Indian Ayurvedic herbal formulation Triphala on adjuvant-induced arthritis in mice and to compare it with that of the non-steroidal antiinflammatory drug indomethacin. Arthritis was induced by intradermal injection of complete Freund's adjuvant (0.1 mL) into the right hind paw of Swiss albino mice. Triphala (1 g/kg/bxwt) and indomethacin (3 mg/kg/bxwt) were administered orally for 8 days (from day 11 to 18) after adjuvant injection. The levels of lysosomal enzymes, tissue marker enzymes, glycoproteins and paw thickness were increased in adjuvant-induced arthritic animals. The body weight was found to be reduced when compared with the control animals. These physical and biochemical changes observed in arthritic animals were altered significantly to near normal conditions after oral administration of Triphala (1 g/kg/bxwt). The results obtained clearly indicate the fact that the Indian Ayurvedic herbal formulation Triphala has promising antiinflammatory activity.
在本研究中，已尝试评估印度阿育吠陀草药配方三果木对小鼠佐剂性关节炎的抗关节炎作用，并将其与非甾体抗炎药吲哚美辛的作用进行比较。通过将完全弗氏佐剂（0.1 mL）皮内注射到瑞士白化小鼠的右后爪诱导关节炎。在佐剂注射后8天（从第11天到第18天）口服给予三果木（1 g/kg/体重）和吲哚美辛（3 mg/kg/体重）。在佐剂诱导的关节炎动物中，溶酶体酶、组织标记酶、糖蛋白水平和爪厚度增加。与对照动物相比，发现体重减轻。在口服给予三果木（1 g/kg/体重）后，关节炎动物中观察到的这些物理和生化变化显著改变至接近正常状态。获得的结果清楚地表明，印度阿育吠陀草药配方三果木有良好的抗炎活性。
