Jantrapirom Salinee, Hirunsatitpron Pannaphak, Potikanond Saranyapin, Nimlamool Wutigri, Hanprasertpong Nutthiya
Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Drosophila Center for Human Diseases and Drug Discovery (DHD), Faculty of Medicine, Chiang Mai, University, Chiang Mai, Thailand.
Front Pharmacol. 2021 Apr 30;12:628198. doi: 10.3389/fphar.2021.628198. eCollection 2021.
Allergic rhinitis (AR) is considered a major nasal condition impacting a large number of people around the world, and it is now becoming a global health problem. Because the underlying mechanisms of AR are complex, the development of single-drug treatment might not be enough to treat a wide spectrum of the disease. Although the standard guidelines classify and provide suitable diagnosis and treatment, the vast majority of people with AR are still without any means of controlling it. Moreover, the benefits of AR drugs are sometimes accompanied by undesirable side effects. Thus, it is becoming a significant challenge to find effective therapies with limited undesirable side effects for a majority of patients suffering from uncontrolled AR. Aller-7/NR-A2, a polyherbal formulation, has revealed promising results in patients by reducing nasal symptoms and eosinophil counts without serious adverse effects. Interestingly, three out of seven of the herbals in the Aller-7/NR-A2 formulation are also found in an Ayurvedic polyherbal formulation known as "Triphala," which is a potential candidate for the treatment of AR. However, there are no current studies that have examined the effects of Triphala on the disease. This review aims to describe the complexity of AR pathophysiology, currently available treatments, and the effects of Triphala on AR in order to help develop it as a promising alternative treatment in the future.
变应性鼻炎（AR）被认为是一种影响全球大量人群的主要鼻部疾病，如今正成为一个全球性的健康问题。由于AR的潜在机制复杂，单一药物治疗的发展可能不足以治疗该疾病的广泛症状。尽管标准指南对其进行了分类并提供了合适的诊断和治疗方法，但绝大多数AR患者仍然无法有效控制病情。此外，AR药物的疗效有时会伴随着不良副作用。因此，对于大多数未得到有效控制的AR患者而言，寻找副作用有限的有效治疗方法正成为一项重大挑战。Aller-7/NR-A2是一种多草药配方，在患者中显示出了有前景的结果，它能减轻鼻部症状并降低嗜酸性粒细胞计数，且无严重不良反应。有趣的是，Aller-7/NR-A2配方中的七种草药中有三种也存在于一种名为“三果木”的阿育吠陀多草药配方中，“三果木”是治疗AR的一个潜在候选药物。然而，目前尚无研究考察过三果木对该疾病的影响。本综述旨在描述AR病理生理学的复杂性、现有的治疗方法以及三果木对AR的影响，以便未来将其开发成为一种有前景的替代治疗方法。
