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三果木在现代健康中的特性及潜在治疗用途。

Triphala's characteristics and potential therapeutic uses in modern health.

作者信息

Bairwa Vinay Kumar, Kashyap Arun Kumar, Meena Pushpa, Jain Buddhi Prakash

机构信息

Department of Zoology, University of Rajasthan Jaipur 302004, RJ, India.

Department of Biotechnology, Govt. E Raghavendra Rao PG. Science College Bilaspur 495001, CG, India.

出版信息

Int J Physiol Pathophysiol Pharmacol. 2025 Apr 25;17(2):19-36. doi: 10.62347/OBSS5026. eCollection 2025.

DOI:10.62347/OBSS5026
PMID:40401115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12089839/
Abstract

Ayurveda, a traditional Indian medical system, offers a comprehensive approach to health promotion, disease prevention, and body rejuvenation, emphasizing wellness, vitality, and holistic well-being. Triphala, a well-established polyherbal Ayurvedic formulation, comprises equal proportions of (Amalaki or Amla), (Bibhitaki or Bahera), and (Haritaki or Harad), demonstrating exceptional efficacy in gastrointestinal health and rejuvenation therapy. Triphala Rasayana, a polyherbal formulation, has been employed in Ayurveda, Siddha, and Unani medicine systems to address various health conditions. Its medicinal attributes include antioxidant, anticancer, antidiabetic, antimicrobial, immunomodulatory, and anticataract properties, making it a vital component in gastrointestinal treatment, particularly for functional gastrointestinal disorders. With its rich history in Ayurveda, Triphala's unique tridoshic properties harmonize the body's three essential energies - Vata, Pitta, and Kapha - fostering overall well-being and diverse health applications. The phytochemical composition of Triphala Rasayana is scrutinized, revealing essential bioactive compounds like phenolic acids, tannins, and flavonoids, which contribute to its antioxidant, anti-inflammatory, and antimicrobial effects. The therapeutic properties of Triphala span antidiabetic, hepatoprotective, and immunomodulatory effects, underpinned by studies demonstrating its benefits for oxidative stress, metabolic disorders, and immune enhancement. The review also underscores Triphala's role in gastrointestinal health, promoting beneficial microbiota and alleviating digestive issues, alongside its cardioprotective effects. Concluding with a call for advanced research into its pharmacodynamics and molecular mechanisms, the document advocates for integrating this potent Ayurvedic remedy into modern therapeutic regimens.

摘要

阿育吠陀是一种传统的印度医学体系,提供了一种全面的促进健康、预防疾病和身体恢复活力的方法,强调健康、活力和整体幸福感。三果木是一种成熟的阿育吠陀多草药配方,由等量的印度醋栗(阿马拉吉或阿育吠陀醋栗)、毗黎勒(毕钵梨或巴诃勒)和诃子(哈里塔基或诃梨勒)组成,在胃肠道健康和恢复活力疗法中显示出卓越的功效。三果木rasayana是一种多草药配方,已被应用于阿育吠陀、悉达和尤那尼医学体系中,以治疗各种健康状况。其药用特性包括抗氧化、抗癌、抗糖尿病、抗菌、免疫调节和抗白内障特性,使其成为胃肠道治疗中的重要组成部分,特别是对于功能性胃肠道疾病。凭借其在阿育吠陀中的悠久历史,三果木独特的三体液特性协调了身体的三种基本能量——风、火、水,促进了整体健康和多种健康应用。对三果木rasayana的植物化学成分进行了仔细研究,发现了酚酸、单宁和黄酮类等重要生物活性化合物,这些化合物有助于其抗氧化、抗炎和抗菌作用。三果木的治疗特性包括抗糖尿病、保肝和免疫调节作用,研究表明其对氧化应激、代谢紊乱和免疫增强有益,从而为这些作用提供了支持。该综述还强调了三果木在胃肠道健康中的作用,促进有益微生物群并缓解消化问题,以及其心脏保护作用。该文献呼吁对其药效学和分子机制进行深入研究,并主张将这种有效的阿育吠陀疗法纳入现代治疗方案。

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Triphala's characteristics and potential therapeutic uses in modern health.三果木在现代健康中的特性及潜在治疗用途。
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本文引用的文献

1
Triphala ameliorates cognitive deficits and anxiety via activation of the Nrf2/HO-1 axis in chronic sleep-deprived mice.三果汤通过激活慢性睡眠剥夺小鼠的 Nrf2/HO-1 轴来改善认知缺陷和焦虑。
Int Immunopharmacol. 2024 Dec 5;142(Pt B):113179. doi: 10.1016/j.intimp.2024.113179. Epub 2024 Sep 18.
2
The antitumor effects of herbal medicine Triphala on oral cancer by inactivating PI3K/Akt signaling pathway: based on the network pharmacology, molecular docking, in vitro and in vivo experimental validation.中药 Triphala 通过抑制 PI3K/Akt 信号通路对口腔癌的抗肿瘤作用:基于网络药理学、分子对接、体外和体内实验验证。
Phytomedicine. 2024 Jun;128:155488. doi: 10.1016/j.phymed.2024.155488. Epub 2024 Mar 11.
3
Evaluation of the anti-hyperlipidemic effects of in high fat diet fed rats: Studies with two combinations.高脂饮食喂养大鼠中[具体物质]抗高脂血症作用的评价:两种组合的研究
Ayu. 2022 Jul-Sep;43(3):98-104. doi: 10.4103/ayu.AYU_74_19. Epub 2023 Oct 9.
4
Preventive mechanisms of Chinese Tibetan medicine Triphala against nonalcoholic fatty liver disease.藏医三果汤预防非酒精性脂肪性肝病的作用机制。
Phytomedicine. 2024 Jan;123:155229. doi: 10.1016/j.phymed.2023.155229. Epub 2023 Nov 20.
5
Bidirectional Effect of Triphala on Modulating Gut-Brain Axis to Improve Cognition in the Murine Model of Alzheimer's Disease.三果汤对调节肠脑轴改善阿尔茨海默病小鼠模型认知功能的双向作用。
Mol Nutr Food Res. 2024 Jul;68(13):e2300104. doi: 10.1002/mnfr.202300104. Epub 2023 Sep 28.
6
Insights into the potential benefits of triphala polyphenols toward the promotion of resilience against stress-induced depression and cognitive impairment.了解三果多酚对增强抗应激性抑郁和认知障碍能力的潜在益处。
Curr Res Food Sci. 2023 Jun 2;6:100527. doi: 10.1016/j.crfs.2023.100527. eCollection 2023.
7
Efficacy of Triphala extracts on the changes of obese fecal microbiome and metabolome in the human gut model.三果木提取物对人体肠道模型中肥胖粪便微生物组和代谢组变化的功效。
J Tradit Complement Med. 2023 Feb 28;13(2):207-217. doi: 10.1016/j.jtcme.2023.02.011. eCollection 2023 Mar.
8
A comprehensive review on the diverse pharmacological perspectives of Retz.关于雷茨(Retz)不同药理学观点的全面综述。
Heliyon. 2022 Aug 14;8(8):e10220. doi: 10.1016/j.heliyon.2022.e10220. eCollection 2022 Aug.
9
GC-MS-employed phytochemical characterization, synergistic antioxidant, and cytotoxic potential of Triphala methanol extract at non-equivalent ratios of its constituents.采用气相色谱-质谱联用技术对三果木甲醇提取物在其成分非等效比例下进行植物化学特征分析、协同抗氧化和细胞毒性潜力研究。
Saudi J Biol Sci. 2022 Jun;29(6):103287. doi: 10.1016/j.sjbs.2022.103287. Epub 2022 Apr 27.
10
Acute esophageal necrosis complicating diabetic ketoacidosis in a patient with type II diabetes mellitus and excessive cola consumption: a case report.一名患有II型糖尿病且过量饮用可乐的患者,糖尿病酮症酸中毒并发急性食管坏死:病例报告
Diabetol Int. 2021 Aug 27;13(1):315-319. doi: 10.1007/s13340-021-00537-y. eCollection 2022 Jan.