Samma S, Yoshida K, Ozono S, Ohara S, Hayashi Y, Tabata S, Uemura H, Iwai A, Hirayama A, Hirao Y
Department of Urology, Nara Medical University.
Jpn J Clin Oncol. 1991 Oct;21(5):340-5.
The significance of two types of vascular invasion (macroscopic tumor thrombus into the renal vein or vena cava inferior and microvascular invasion) as prognostic factors in renal cell carcinoma is analyzed in 121 patients treated at the Department of Urology, Nara Medical University. The data indicate there to be close correlations between tumor thrombus, microvascular invasion and distant metastasis. In patients with tumor thrombus, however, the prognosis is not as poor when surgical removal of the tumor thrombus is successfully performed as when it is not. In contrast, the prognosis of patients with positive microvascular invasion is significantly worse than that of those with a negative finding. Microvascular invasion appears to be a significant prognostic factor in renal cell carcinoma in addition to well-known factors such as tumor stage, tumor grade, tumor thrombus and distant metastasis. To detect microvascular invasion, the histological examination should be extended to give as much detail as possible.
奈良医科大学泌尿外科对121例接受治疗的肾细胞癌患者分析了两种血管侵犯（肉眼可见肿瘤血栓侵入肾静脉或下腔静脉以及微血管侵犯）作为预后因素的意义。数据表明，肿瘤血栓、微血管侵犯与远处转移之间存在密切关联。然而，在有肿瘤血栓的患者中，成功进行肿瘤血栓手术切除后的预后并不像未成功切除时那么差。相比之下，微血管侵犯阳性患者的预后明显比阴性患者差。除了肿瘤分期、肿瘤分级、肿瘤血栓和远处转移等众所周知的因素外，微血管侵犯似乎也是肾细胞癌的一个重要预后因素。为了检测微血管侵犯，组织学检查应尽可能详细。
