Mijaljica Dalibor, Prescott Mark, Klionsky Daniel J, Devenish Rodney J
Department of Biochemistry and Molecular Biology, and the ARC Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton Campus, Victoria, Australia.
Autophagy. 2007 Sep-Oct;3(5):417-21. doi: 10.4161/auto.4441. Epub 2007 May 16.
The vacuole of yeast plays an important role in pH- and ion-homeostasis. Another important function of the vacuole, especially during nutrient deprivation, is the degradation of proteins, other macromolecules and organelles. To deliver these components into the vacuolar lumen, specific and sophisticated transport pathways such as autophagy have evolved. This review will first look at autophagy and its relationship to vacuole homeostasis, then move to the topic of vacuole self-degradation and possible reasons for its existence, and close by pointing very briefly to some areas for further research in these topics.
酵母的液泡在pH值和离子稳态方面发挥着重要作用。液泡的另一个重要功能，尤其是在营养缺乏期间，是蛋白质、其他大分子和细胞器的降解。为了将这些成分输送到液泡腔中，已经进化出了诸如自噬等特定而复杂的运输途径。本综述将首先探讨自噬及其与液泡稳态的关系，然后转向液泡自我降解及其存在的可能原因这一主题，并最后简要指出这些主题中一些有待进一步研究的领域。
