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手术洞察:根治性阴道宫颈切除术作为宫颈癌保留生育功能的一种方法

Surgery insight: radical vaginal trachelectomy as a method of fertility preservation for cervical cancer.

作者信息

Beiner Mario E, Covens Allan

机构信息

Gynecologic Oncology Division, University of Toronto, Toronto, ON, Canada.

出版信息

Nat Clin Pract Oncol. 2007 Jun;4(6):353-61. doi: 10.1038/ncponc0822.

Abstract

Over the past decade, the treatment of cervical cancer has evolved with an increased emphasis on preservation of fertility. There has been a gradual abandonment of radical surgical procedures in favor of more conservative techniques in an effort to decrease morbidity and preserve fertility without compromising overall survival. Radical vaginal trachelectomy (RVT) with laparoscopic pelvic lymphadenectomy is a fertility-preserving procedure that has recently gained worldwide acceptance as a method of surgically treating small invasive cancers of the cervix. Since the original description of RVT by Daniel Dargent in 1994, over 500 cases of utilization of this technique have been reported in the literature, with over 100 live births reported following this procedure. The morbidity associated with RVT is low, with a tumor recurrence rate of 5% and a mortality rate of 3%. The current literature indicates no difference in the rate of recurrence with this technique compared with radical hysterectomy when proper selection criteria are used. Combining RVT with laparoscopic sentinel lymph-node biopsy can further reduce the duration, extent, and complications of surgery.

摘要

在过去十年中,宫颈癌的治疗方法不断演变,越来越重视保留生育能力。为了降低发病率并在不影响总体生存率的前提下保留生育能力,人们逐渐摒弃了根治性手术,转而采用更为保守的技术。根治性阴道宫颈切除术(RVT)联合腹腔镜盆腔淋巴结清扫术是一种保留生育能力的手术,最近作为一种治疗宫颈小浸润癌的手术方法在全球范围内得到了认可。自1994年丹尼尔·达让首次描述RVT以来,文献中已报道了500多例该技术的应用,其中超过100例患者术后成功分娩。RVT相关的发病率较低,肿瘤复发率为5%,死亡率为3%。目前的文献表明,在使用适当的选择标准时,该技术与根治性子宫切除术相比,复发率没有差异。将RVT与腹腔镜前哨淋巴结活检相结合可以进一步缩短手术时间、减少手术范围并降低手术并发症。

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