Zakashansky Konstantin, Bradley William H, Chuang Linus, Rahaman Jamal, Dottino Peter
Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine, New York, NY, USA.
Mt Sinai J Med. 2009 Dec;76(6):567-76. doi: 10.1002/msj.20149.
Recent advances in the surgical management of early cervical cancer, including abdominal, laparoscopic, vaginal, and robotic approaches to radical hysterectomy as well as fertility-sparing radical trachelectomy, are reviewed. The nerve-sparing abdominal radical hysterectomy technique allows for a significant reduction in postoperative bladder morbidity. Radical vaginal hysterectomy with laparoscopic lymph node dissection is a well-recognized technique that offers excellent cure rates without abdominal entry as well as reduced postoperative febrile and gastrointestinal morbidity. Total laparoscopic radical hysterectomy is a minimally invasive alternative to the traditional abdominal radical hysterectomy approach and yields a comparable safety profile with a significant reduction in blood loss and hospital stay. Robotic surgery is becoming more widely accepted in the management of gynecologic cancers, including radical hysterectomy for early cervical cancer. Young women desiring to bear children in the future may be candidates for fertility preservation options, and the radical trachelectomy operation has been described and performed with abdominal, vaginal, laparoscopic, and robotic techniques. There are a number of surgical options for the treatment of women with early cervical cancer. The feasibility and safety of some of these techniques have been well established, whereas for others, the oncological outcome data are only preliminary. The decision to use newer techniques should be directed by patient variables as well as the surgeon's training and competence with laparoscopy, robotics, or vaginal surgery.
本文综述了早期宫颈癌外科治疗的最新进展,包括腹式、腹腔镜、经阴道及机器人辅助根治性子宫切除术以及保留生育功能的根治性宫颈切除术。保留神经的腹式根治性子宫切除术可显著降低术后膀胱并发症的发生率。腹腔镜下淋巴结清扫的经阴道根治性子宫切除术是一种公认的技术,该技术无需开腹即可获得良好的治愈率,且术后发热及胃肠道并发症减少。全腹腔镜根治性子宫切除术是传统腹式根治性子宫切除术的微创替代方法,其安全性相当,失血和住院时间显著减少。机器人手术在妇科癌症治疗中的应用越来越广泛,包括早期宫颈癌的根治性子宫切除术。希望未来生育的年轻女性可能适合保留生育功能的手术,根治性宫颈切除术已通过腹式、经阴道、腹腔镜及机器人技术进行描述和实施。早期宫颈癌女性患者有多种手术治疗选择。其中一些技术的可行性和安全性已得到充分证实,而其他技术的肿瘤学结局数据仅为初步结果。新技术的应用决策应根据患者个体情况以及外科医生在腹腔镜、机器人手术或经阴道手术方面的培训和能力来决定。