Brunner Jürgen, Scholl-Bürgi Sabine, Zimmerhackl Lothar-Bernd
Department of Pediatrics, Innsbruck Medical School, Anichstrasse 35, 6020, Innsbruck, Austria.
Rheumatol Int. 2007 Oct;27(12):1171-2. doi: 10.1007/s00296-007-0363-0. Epub 2007 May 30.
Sarcoidosis is a chronic granulomatous inflammation. The clinical spectrum in childhood is heterogeneous. Angiotensin converting enzyme (ACE) activity is used as a marker for disease activity. Human chitotriosidase is produced in macrophages. In this study serum chitotriosidase levels were significantly higher in active sarcoidosis, than in inactive disease or healthy controls. Serum chitotriosidase concentrations may be a useful marker for monitoring disease activity in sarcoidosis.
结节病是一种慢性肉芽肿性炎症。儿童期的临床谱具有异质性。血管紧张素转换酶（ACE）活性被用作疾病活动的标志物。人壳三糖苷酶由巨噬细胞产生。在本研究中，活动期结节病患者的血清壳三糖苷酶水平显著高于非活动期疾病患者或健康对照。血清壳三糖苷酶浓度可能是监测结节病疾病活动的有用标志物。
