Coombes S, Timofeeva Y, Svensson C-M, Lord G J, Josić K, Cox S J, Colbert C M
Department of Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, UK.
Biol Cybern. 2007 Aug;97(2):137-49. doi: 10.1007/s00422-007-0161-5. Epub 2007 May 30.
Dendrites form the major components of neurons. They are complex branching structures that receive and process thousands of synaptic inputs from other neurons. It is well known that dendritic morphology plays an important role in the function of dendrites. Another important contribution to the response characteristics of a single neuron comes from the intrinsic resonant properties of dendritic membrane. In this paper we combine the effects of dendritic branching and resonant membrane dynamics by generalising the "sum-over-trips" approach (Abbott et al. in Biol Cybernetics 66, 49-60 1991). To illustrate how this formalism can shed light on the role of architecture and resonances in determining neuronal output we consider dual recording and reconstruction data from a rat CA1 hippocampal pyramidal cell. Specifically we explore the way in which an Ih current contributes to a voltage overshoot at the soma.
树突构成了神经元的主要组成部分。它们是复杂的分支结构，接收并处理来自其他神经元的数千个突触输入。众所周知，树突形态在树突功能中起着重要作用。单个神经元反应特性的另一个重要贡献来自树突膜的固有共振特性。在本文中，我们通过推广“行程求和”方法（阿博特等人，《生物控制论》66卷，49 - 60页，1991年），将树突分支和共振膜动力学的影响结合起来。为了说明这种形式体系如何揭示结构和共振在决定神经元输出中的作用，我们考虑来自大鼠CA1海马锥体细胞的双记录和重建数据。具体而言，我们探讨了Ih电流对胞体电压过冲的贡献方式。
