Spitzer M S, Szurman P, Aisenbrey S, Rohrbach J M
Department of Ophthalmology I, University of Tübingen, Tubingen, Germany.
Eur J Ophthalmol. 2007 May-Jun;17(3):433-6. doi: 10.1177/112067210701700328.
To report a corneal transplant complication associated with intracameral recombinant tissue plasminogen activator (rTPA) treatment of postoperative fibrin reaction.
In a 71-year-old patient, a triple procedure was performed for perforated rheumatic ulcer and secondary cataract.
A dense band keratopathy developed rapidly within 36 hours after the use of intracameral injection of rTPA for the treatment of a dense fibrin clot.
This is the first report of rapid development of massive band keratopathy in a corneal graft after triple procedure and treatment with intracameral rTPA. Intracameral rTPA should be used with caution in patients with attenuated endothelium.
