使用11号和X号染色体上的DNA标记对情感障碍进行连锁分析。

Linkage analysis of affective disorder using DNA markers on chromosomes 11 and X.

作者信息

Nanko S, Kobayashi M, Gamou S, Kudoh J, Shimizu N, Takazawa N, Kazamatsuri H, Furusho T

机构信息

Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.

出版信息

Jpn J Psychiatry Neurol. 1991 Mar;45(1):53-6. doi: 10.1111/j.1440-1819.1991.tb00505.x.

DOI:10.1111/j.1440-1819.1991.tb00505.x

PMID:1753490

Abstract

We have investigated two pedigrees in an attempt to detect the putative linkages between affective disorder and c-Ha-ras-1 oncogene and the insulin gene on chromosome 11, or hypoxanthine phosphoribosyltransferase (HPRT) on X chromosome. The linkage between affective disorders and the markers on chromosomes 11 and X was ruled out with the assumption of no recombination.

摘要

我们研究了两个家系，试图检测情感障碍与11号染色体上的c-Ha-ras-1癌基因和胰岛素基因，或X染色体上的次黄嘌呤磷酸核糖转移酶（HPRT）之间的假定连锁关系。在无重组的假设下，情感障碍与11号染色体和X染色体上标记之间的连锁关系被排除。