Edden Richard A E, Pomper Martin G, Barker Peter B
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Magn Reson Med. 2007 Jun;57(6):977-82. doi: 10.1002/mrm.21234.
A method is described that allows the in vivo differentiation of N-acetyl aspartate (NAA) from N-acetyl aspartyl glutamate (NAAG) by in vivo MR spectroscopy (MRS) at 3 Tesla (3T). The method, which is based on MEGA-point-resolved spectroscopy (PRESS) editing, selectively targets the aspartyl spin system of one species while deliberately removing the other species from the spectrum. This allows quantitative measurements of NAA and NAAG without the need for fitting of unresolved peaks. White matter concentrations of NAA (6.7 +/- 0.3 mM) and NAAG (2.2 +/- 0.3 mM) were measured in 10 healthy volunteers to demonstrate the method.
本文描述了一种方法，该方法可通过在3特斯拉（3T）下进行体内磁共振波谱（MRS），在体内区分N-乙酰天门冬氨酸（NAA）和N-乙酰天门冬氨酰谷氨酸（NAAG）。该方法基于MEGA点分辨波谱（PRESS）编辑，选择性地针对一种物质的天门冬氨酰自旋系统，同时有意从谱图中去除另一种物质。这使得无需对未解析的峰进行拟合即可对NAA和NAAG进行定量测量。在10名健康志愿者中测量了白质中NAA（6.7±0.3 mM）和NAAG（2.2±0.3 mM）的浓度，以证明该方法的可行性。
