Kim Ji Youn, Lee Won Yong, Chung Eun Joo, Dhong Hun-Jong
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Mov Disord. 2007 Aug 15;22(11):1563-6. doi: 10.1002/mds.21490.
Olfactory deficit is known to occur frequently in Parkinson's disease (PD). This study aimed to explore olfactory deficit in PD and to investigate its possible correlation with the disease severity or the depth of the olfactory sulcus. Fifty-nine PD patients and 25 normal controls were examined by the odor identification test with the crosscultural smell identification test (CC-SIT). Among these subjects, the depth of the olfactory sulcus of 42 PD patients and 8 controls was measured in the plane of the posterior tangent through the eyeballs using the coronal view brain MRI. The CC-SIT scores of the PD patients were significantly lower than those of the normal control (P<0.001). However, CC-SIT did not correlate with the disease duration, H-Y stage, score of UPDRS Part III, or the depth of either side of the olfactory sulcus (P>0.05). Our study confirms that CC-SIT is a helpful test in detecting the olfactory deficit in Korean PD patients. The absence of correlation of olfactory deficit with the disease severity or the depth of olfactory sulcus may suggest that olfactory loss precede the development of motor signs and not be a primary consequence of damage to the olfactory sulcus.
众所周知，嗅觉减退在帕金森病（PD）中经常出现。本研究旨在探讨帕金森病患者的嗅觉减退情况，并研究其与疾病严重程度或嗅沟深度之间的可能相关性。采用跨文化嗅觉识别测试（CC-SIT）气味识别试验对59例帕金森病患者和25名正常对照者进行检查。在这些受试者中，使用冠状位脑MRI在通过眼球的后切线平面上测量了42例帕金森病患者和8名对照者的嗅沟深度。帕金森病患者的CC-SIT评分显著低于正常对照组（P<0.001）。然而，CC-SIT与病程、H-Y分期、统一帕金森病评定量表（UPDRS）第三部分评分或两侧嗅沟深度均无相关性（P>0.05）。我们的研究证实，CC-SIT有助于检测韩国帕金森病患者的嗅觉减退。嗅觉减退与疾病严重程度或嗅沟深度无相关性，这可能表明嗅觉丧失先于运动症状出现，而非嗅沟损伤的主要后果。
